Full-back Aaron Cresswell, injured after an hour of the 2-1 loss to Manchester City on Sunday, did not recover in time to face the Seagulls, Vladimír Coufal reintroduced into the starting XI in his place.
Jarrod Bowen is reintroduced to the XI, meanwhile, at the expense of Arthur Masuaku, who is named among Moyes’ replacements on Wednesday.
The changes mean Ben Johnson – who scored his first professional goal against Brighton in the corresponding game last season – is likely to move to the left side of the defense for his seventh consecutive Premier League start.
Coufal is expected to defend on the opposite flank of a four-man defender also including Craig Dawson and Kurt Zouma.
Declan Rice will once again wear the captain’s armband – rainbow colored, to show Club’s support for the 2021 Rainbow Laces campaign – and anchor the midfielder alongside his regular midfielder Tomáš Souček.
In front of them, the exciting triumvirate of Pablo Fornals, Saïd Benrahma and Jarrod Bowen, who supports Michail Antonio in attack.
Moyes could appeal to many options off the bench, including, for the second time in a week, 17-year-old forward Sonny Perkins, who made his first-team debut against Rapid Vienna in the UEFA Europa League last week. .
The West Ham substitutes bench also includes goalkeeper Alphonse Areola; defenders Issa Diop and Arthur Masuaku; midfielders Alex Král and Club captain Mark Noble; and forwards Nikola Vlašić and Andriy Yarmolenko.
West Ham United: Fabiański, Coufal, Dawson, Zouma, Johnson, Rice (c), Souček, Fornals, Benrahma, Bowen, Antonio
Sous-titres : Areola (GK), Diop, Masuaku, Noble, King, Lanzini, Vlasic, Yarmolenko, Perkins
Brighton and Hove Albion: Sánchez, Veltman, Webster, Dunk (c), Cucurella, Bissouma, Lallana, Moder, Sarmiento, Trossard, Maupay
Sous-titres : Steele (GK), Lamptey, Mac Allister, Mwepu, Groß, March, Duffy, Locadia, Burn
Arbitrator: Chris Kavanagh