Police said they were called at 6:45 p.m. in an accident involving multiple vehicles and pedestrians on Riverside Drive west of Wonderland Road.
Paramedics took several pedestrians to hospital with injuries ranging from minor to fatal, police said.
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The exact number of vehicles involved and the number of pedestrians injured were not immediately communicated.
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Police said everyone involved in the incident remained at the scene. What may have led to the collision is unclear.
Wonderland Road is closed between Springbank Drive and Kingsway Avenue, while Riverside Drive is closed between Braemar Crescent and Warren Road.
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