Mohamed Salah and Divock Origi both scored as the changed Reds sealed a 2-1 victory in Italy.
Liverpool will now aim to keep pace with Premier League leaders Manchester City when Steven Gerrard returns to Anfield with Aston Villa on Saturday afternoon.
And here we anticipate what changes Jurgen Klopp could make when his team are next in action.
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Claiming Konate’s Stakes
Klopp chose to rotate his resources midweek with several players not even making the trip to San Siro.
Among those was Virgil van Dijk, who is expected to return in the starting XI against Villa.
However, Ibrahima Konate’s display at Milan has given him a strong claim to line up alongside Van Dijk in the heart of the defense, although Joel Matip remains the favorite. Nat Phillips and Joe Gomez, who returned from injury on Tuesday, are the other options.
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Kostas Tsimikas and Neco Williams also did well in Italy, but Andy Robertson and Trent Alexander-Arnold are set to replace the duo at left-back and right-back respectively.
Alisson Becker is the undisputed number one between the sticks, Caoimhin Kelleher will likely have to wait until the Carabao Cup quarter-final against Leicester City in two weeks for his next outing.
Ox in the seat of the box?
Liverpool now have a plethora of options in midfield, with players returning from injury and others in great shape.
Jordan Henderson and Thiago Alcantara did not make it to Italy while Fabinho was limited to a late appearance on the bench.
In their absence, Alex Oxlade-Chamberlain impressed as teenager Tyler Morton once again demonstrated why he was highly rated at the Academy.
The essential news from Liverpool FC
Naby Keita has returned to action after more than a month away with a hamstring problem while James Milner is available this weekend after being suspended in the Champions League.
Harvey Elliott remains out, while Curtis Jones awaits the green light from medics to resume full training after an abnormal eye injury.
The question of origin
Mohamed Salah and Sadio Mane were both keen to play against Milan, and contributed a goal and an assist before being substituted in the second half.
Divock Origi, however, won the match for the second time in a week, with Klopp determining whether the Belgian retains his starting role against Villa.
One choice would be to let Mane rest and place Diogo Jota on the left flank, although the Portuguese are more likely to be called up in the top three picks.
Another alternative is Takumi Minamino, who started as a midfielder in Italy. Roberto Firmino is still on the sidelines.