According to the Robert Koch Institute for Health Surveillance, there have been 50,196 additional cases of COVID-19 in the past 24 hours, with 235 deaths.
Germany is among a number of European countries facing a further rise in the number of cases and has seen a record number of infections in recent days.
Outgoing Chancellor Angela Merkel on Wednesday described the upsurge in infections in the country as “dramatic”, particularly noticeable since October.
“The pandemic is spreading dramatically again,” his spokesperson said, calling on regional health authorities to take additional measures to contain the situation.
Pressure on hospital services is also increasing.
Several hospitals have said in recent days that they are working to their limits again and have intensive care units so full of COVID-19 patients that they cannot admit new patients.
“We have a real emergency at the moment,” said Christian Drosten, head of the virology department at the Charite hospital in Berlin earlier this week.
The epidemic is attributed in part to the relatively low vaccination rate of the population in Germany, at just over 67 percent.
Several particularly affected states, such as Saxony, Bavaria and more recently Berlin, have introduced new restrictions targeting unvaccinated people.
From Monday, Berlin will ban unvaccinated people from restaurants without terraces, bars, gyms and hairdressers.
A negative test will no longer allow access to these public places if users are not vaccinated or cannot prove that they are cured of the disease.
In total, nearly 4.9 million people have been infected in Germany since the start of the pandemic.