The Juventus star played 75 minutes in Thursday night’s spectacular 3-2 win over Belgium in the semi-final, but will miss against Luis Enrique’s side.
The news is a blow to Didier Deschamps, who is already without N’Golo Kante after the Chelsea man tested positive for the virus, but could pave the way for young Monegasque Aurélien Tchouaméni to make his second senior start.
Spain, meanwhile, are hopeful that Ferran Torres will be able to lead the line after scoring twice in their semi-final victory over Italy in Milan.
Torres scored two superb first-half goals before suffering an injury shortly after the break, but the problem is considered minor.
Enrique looks likely to stick with most of the squad who were so impressive at San Siro, which would mean 17-year-old Barcelona midfielder Gavi would retain his place after becoming Spain’s youngest player. story.
Fellow Yeremi Pino is hoping to move Pablo Sarabia to the right wing after an impressive appearance on the bench.
Spain predicted XI: Unai Simon; Azpilicueta, P. Torres, Laporte, Alonson; Busquets, Koke, Gavi; Pino, Oyarzabal, F. Torres.
France predicted XI: Lloris; Kounde, Varane, L. Hernandez; T. Hernandez, Pogba, Tchouaméni, Pavard; Griezmann; Mbappe, Benzema.