Who is most likely to develop severe COVID-19 even after a second jab? – .

Who is most likely to develop severe COVID-19 even after a second jab? – .

Seniors with a high rate of underlying medical conditions and immunosuppression are more likely to contract coronavirus and develop a severe case of COVID-19 even after being fully vaccinated, according to a world-first study conducted in Israel .

A minority of people vaccinated will contract coronavirus and a small percentage of those people will eventually be hospitalized because of the virus, despite the vaccine. This is called a breakthrough infection.

But who are these people ?

A team of Israeli doctors, led by Professor Tal Brosh, head of the infectious diseases unit at Samson Assuta Ashdod Teaching Hospital, studied 152 fully vaccinated patients from 17 hospitals who developed COVID-19 over seven days after the second dose of vaccine and which required hospitalization before the end of April 2021.

The cohort was small because few vaccinated people who contract the coronavirus end up developing severe infections, as the vaccine is 97% to 98% effective against the standard variant – and is found to be almost as effective against the Delta variant. . So far, despite a rapid increase in coronavirus cases in Israel, the number of severe cases appears to be increasing only slowly.

“Overall, we can say that the bottom line is that these are not healthy people,” Brosh said in an interview with The Jerusalem Post. “Almost all (96%) had comorbidities: heart disease, lung disease, kidney disease, dementia, cancer or other common illnesses. Thus, people who contract breakthrough infections and are admitted are sicker than the usual person. “

Of those who ended up in hospital, 38 had what has been defined as “poor results,” meaning they were mechanically ventilated or died.

Specifically, 71% suffered from hypertension; 48% of diabetes; 27% congestive heart failure; 24% chronic renal failure; 24% chronic lung disease; 19% dementia; and 24% cancer. Only 6% had no underlying medical problem.

In addition, the study showed that 40% of the patients were immunocompromised.

“If your immune system is not functioning well, you are at a higher risk of not developing protection against vaccination,” Brosh said, adding that about 35% of patients did not have detectable antibodies, which means that they had failed to develop an immune response to the vaccine. .

The median time from the second dose to hospitalization was 40 days. The median age of the patients was 71 years. In most cases, the source of the patient’s infection was unknown.

Brosh said that although this study was conducted when the Alpha variant was active in Israel and the majority of cases had this viral strain, he said it is likely that the characteristics still apply today – to those infected with the Delta variant which now comprises over 90% of infections in Israel.

He said the Delta variant appears to break through the vaccine more than its predecessor Alpha, but it’s still unclear whether the variant causes more serious breakthrough infections – despite some suggestions from the Department of Health, Brosh said.

Still, he said there was a take home message for the public:

“If you’re older and have comorbidities – and certainly have a lot of comorbidities – or are immunocompromised, you can’t assume that you’ll be well protected from the vaccine,” Brosh said. “When there is a lot of transmission in the community, you should take care of yourself. ”


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