Meghan and Harry resigned as royals last year and moved to California with their son Archie. The couple revealed they are expecting their second children this year.
Royal expert Ingrid Seward said the Queen suffered ‘sadness’ upon barely seeing Archie and was unlikely to meet their new baby.
Ms Seward said: ‘The Sussexes, who have barely set foot in the UK since moving to the US and are unlikely to return soon after their interview with Oprah, have sent shockwaves through the Royal family.
“Meghan is due to give birth to their daughter – the Queen’s 11th great-grandchild – shortly, but unless Meghan and Harry bring the baby to Britain the Queen will not be able to meet her.
The Queen was last seen with all of her great-grandchildren in a photo released after the death of Prince Philip.
Ms Seward said the Queen’s grandchildren and her great-grandchildren are “what keeps her going”.
The royal expert said: “She is close to them all, mentioning them in her Christmas speeches, in her letters and in her conversations.
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Meghan and Harry shocked the world when they announced their intention to step down as senior royals.
Earlier this year, the Sussexes made a series of explosive allegations about the Royal Family during a controversial interview with Winfrey.
The Duke and Duchess have also accused an unnamed royal, not the Queen or her late husband Prince Philip, of expressing concerns over the dark color of their son Archie’s skin before he was born.
Last week Harry made more statements about his time as a member of the Royal Family.
Sitting down with Dax Shepard and Monica Padman on the Armchair Expert podcast, Harry said he didn’t want to pass the pain of his own experience on to his son Archie and his future daughter.
“It’s a lot of genetic pain and suffering that’s passed on anyway, so we parents should do our best to try and say, ‘You know what happened to me, I’m going to make sure that this is not the case ‘it does not happen to you. ”
Since resigning, the couple have signed multi-million dollar deals with Spotify and Netflix.