Manchester United boss Solskjaer plans to announce the changes against Leicester on Tuesday night with a stronger side likely to face Liverpool on Thursday.
It comes with United facing three games in five days in a hectic end to the campaign, but Solskjaer says fielding all of his best players in every game would risk injuring them.
United must not lose points against Leicester to prevent City from being crowned champions, but Solskjaer has warned he needs to think about the bigger picture ahead of the Europa League final and the Euros this summer.
Solskjaer said: “I wish I could have said, let’s go all out in every game, but it’s impossible. It’s the hardest thing for me to know that if I play this XI on Tuesday, then again on Thursday, it’s impossible, I’m taking too many risks by injuring them.
“Speaking of integrity in the league and stuff, don’t blame me when I have to make changes because I have to. It’s not safe for them to play all four, so I have to prioritize.
“We’re going to sit down with the sports scientists, we can have a theoretical team now, but we’ll have to see how they react when they arrive tomorrow and Tuesday morning, and then pick a team on Tuesday afternoon.”
United defender Harry Maguire is hoping his ankle injury is not too serious, but Solskjaer will mark the changes against Leicester with a chance for young players, marginal players and mass changes with Edinson Cavani, Nemanja Matic and Eric Bailly all ready to start.
Solskjaer has also confirmed that United are reviewing security ahead of Leicester’s game and, in particular, ahead of Liverpool on Thursday as that game was postponed after mass protests.
The United boss pleaded with fans not to be violent and said they would listen to their protests.
Solskajer added: “Security measures are being reviewed and I hope we can keep the protests going, if there are any protests, cut them down out loud, without anything violent.
“We want to listen, the players want to play the game, we play Liverpool and of course we want to beat Liverpool and we want to beat Leicester so we’re going to do whatever we can to make our fans celebrate what we’re doing on the pitch.