He had announced he was battling cancer in March, after being first diagnosed with a kidney tumor in 2012.
The tumor was removed, but he later confirmed he was battling cancer again in a 2019 statement.
It was McLoughlin who scored the goal that led the Republic of Ireland to the 1994 World Cup, when he scored in a qualifying match against Northern Ireland at Windsor Park in Belfast.
He was part of Jack Charlton’s team at the tournament in the United States and won 42 caps for the Irish in total between 1990 and 1999.
He played most of his club career for Portsmouth, having started as a trainee at Manchester United, where he failed to make the first team.
Born in Manchester, McLoughlin played more than 100 times for Swindon as he worked his way through the game as a young player, before moving on to Torquay, Southampton and Aston Villa.
It was at Portsmouth that he would come to spend most of his club career, appearing more than 300 times for Pompey between 1992 and 1999.
He later had stints in Wigan, Rochdale and Forest Green Rovers before retiring in 2003 and returning to local media work in Portsmouth.
He joined Portsmouth’s Academy as a coach in 2011, and became first-team coach in 2013 when he assisted manager Guy Whittingham.
He would later have a spell as a coach at Swindon’s Academy which lasted until early this year.