Grodin, who was best known for his roles in The Heartbreak Kid, Midnight Run and Beethoven, died of bone marrow cancer at his home in Wilton, Connecticut, his son Nicholas said.
In 1988, he starred alongside Robert De Niro in Midnight Run, where Grodin played a runaway mafia accountant who is tracked down by him.
Grodin, born Charles Grodinsky in Pittsburgh in 1935, was the son of a dry goods wholesaler who died at the age of 18.
He played basketball and later described himself as “a tough kid, always kicked out of the classroom.”
He studied at the University of Miami and the Pittsburgh Playhouse, worked in the theater during the summer, then struggled in New York City, earning money overnight as a cab driver and postal clerk all by studying theater by day.
In 1970 he appeared in the movie Catch-22, before rising to fame two years later in The Heartbreak Kid.
He played the role of a newly married man who ditched his bride to pursue a beautiful, rich blonde played by Cybill Shepherd. For this role, he was nominated for the best actor award at the Golden Globes.
Grodin was also in Dave, The Woman in Red, Rosemary’s Baby, and Heaven Can Wait.
And on Broadway, he starred with Ellen Burstyn in the 1970s Broadway comedy Same Time, Next Year.
Beethoven brought him success in the genre of family-animal comedy in 1992, playing a father. When asked why he joined the project, he said he was happy to get the job.
He said: “I am not in great demand. It’s not like I have this stack of wonderful offers. I’m just glad they wanted me. “
Also in the 1990s, he started working on radio and television, establishing himself as a liberal commentator.
He has also written plays and scripts for television, winning an Emmy in 1997 for his work on The Paul Simon Special, and writing books reflecting the ups and downs of showbusiness.
In his 1989 book, It Would Be So Good If You Weren’t Here, he wrote that actors shouldn’t be thinking so much about moving forward as they are about getting as good as they can be, so you’re ready when you want to. have the opportunity ”.
“I did, so I didn’t suffer the frustration of all the rejections. They just gave me more time. “
American actress Kathy Griffin paid tribute to Grodin on Twitter, saying the actor made her “laugh with joy”.
Patton Oswalt, who starred in Brooklyn Nine-Nine, Two and a Half Men and Community, also paid tribute.