AstraZeneca blood clot puzzle solved as scientists know how to stop it –

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AstraZeneca blood clot puzzle solved as scientists know how to stop it – fr


In extremely rare cases, the jab can produce blood clots (Photo: Getty / AP)

German scientists claim to have discovered the cause of rare blood clots linked to AstraZeneca and Johnson & Johnson injections.

Experts explained that the clots were caused by “floating mutant proteins” and said they knew how to prevent this from happening.

Their theory is that the clots occur because the vaccine sends the spike protein directly into the cell nucleus.

Women over 50 seem most at risk for these clots, but as mentioned, they are extremely common.

The AstraZeneca vaccine has been linked to just 309 cases of coagulation and 56 deaths in the UK – out of 33 million vaccines.

Meanwhile, the J&J vaccine has been linked to 28 cases in the United States out of more than 10,400,000 injections.

Researchers at Goethe University in Frankfurt and the University of Ulm in Helmholtz, Germany say the problem lies with the adenovirus vector.

The way the AstraZeneca jab works is by adding the coronavirus spike protein gene to another virus called adenovirus. Adenoviruses are common viruses that usually cause colds or the flu and are what allow them to get into the body and work.

Lead scientist Rolf Marschalek explains in a pre-print article published Wednesday that this method adds the spike protein to the nucleus of the cell rather than the cytosol fluid inside the cell.

Clinical pharmacist Ellie Morton prepares to administer Oxford AstraZeneca Covid-19 vaccine (Chris Jackson / Getty Images)

Once inside the cell nucleus, parts of the spike protein separate, creating mutant variants. These are unable to bind to the membrane and become “floating mutant proteins” which can trigger blood clots in about 1 in 100,000 people.

However, scientists say vaccines can be tailored to avoid this side effect, according to the Financial Times.

“With the data we have in our hands, we can tell companies how to mutate these sequences, coding for the spike protein in a way that avoids unintentional splicing reactions,” Professor Marschalek said.

The Medicines and Health Products Regulatory Agency (MHRA) has said that while the estimated incidence rate of blood clot cases has increased over time, the number of cases remains extremely low against the backdrop of the millions of doses administered.

The regulator’s position remains that the benefits of the AstraZeneca vaccine continue to outweigh the risks for the vast majority of people.

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