A Pan-Canadian Study to Investigate Combined and Paired Vaccine Doses – fr

A Pan-Canadian Study to Investigate Combined and Paired Vaccine Doses – fr

TORONTO – A new pan-Canadian study will examine the effect of using different doses of COVID-19 vaccine in Canadian adults to determine whether combination and pairing vaccines give a strong immune response and how long the response lasts.

The study, announced Thursday, will examine the use of different vaccines for the first and second doses in 1,300 adult participants. The study will be conducted in collaboration with the COVID-19 Immunity Working Group, the Vaccine Surveillance Reference Group, the Canadian Immunization Research Network and Dalhousie University.

“As questions of vaccine interchangeability arise and other dosing intervals are used in public health programs, our goal is to determine: what are the effects of different vaccine dosing intervals on immunity and security? Said Dr. Joanne Langley, co-principal investigator of the study and professor at Dalhousie University, in a press release.

The study will also seek to determine the immune response created by the mixing and pairing of vaccines, and the duration of the immune response.

The study, called “Mixing and Matching Second Dose of COVID-19 Vaccine for Safety and Immunogenicity,” or MOSAIC for short, will begin recruiting participants as soon as possible at Canadian Network clinical trial sites. immunization research. These sites are located in Nova Scotia, Quebec, Ontario, Manitoba, Alberta and British Columbia

There are currently four vaccines authorized for emergency use in Canada. However, several provinces have suspended the use of the AstraZeneca COVID-19 vaccine for the first doses due to rare blood clots.

Canada’s vaccine is still in phase three trials, but could be added to the study pending approval.

“As more vaccines become available, they will be added to the study to fill knowledge gaps in public health. Study data will be shared regularly with public health officials to help inform decision making for the ongoing vaccine deployment in Canada, ”said study co-principal investigator and professor Dr. Manish Sadarangani. an associate at the University of British Columbia, said in the statement.

Currently, NACI and Health Canada recommend a four-month interval between doses of the COVID-19 vaccine, except in people at high risk, to ensure that as many people as possible receive a first dose. . The study aims to help guide future vaccine deployment plans, the statement said.

Other countries are also conducting clinical trials to see if it is safe to mix and match the doses of the vaccine.

Preliminary results from a British and Spanish study suggest that the combination is ultimately safe and that the mixed dose regimen appeared to cause the immune system to produce many more antibodies.

“In addition to international data, this Canadian study will help inform Canada’s public health recommendations on the possibility of using different combinations of vaccines for the first and second dose, as well as different dosing intervals,” Dr. Theresa Tam, Canada’s chief public health officer, said in a press release.

People 18 years of age or older can participate in the study by clicking here.


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