Public Health England said it was studying the new strain containing the same spike E484K protein found in the Manaus mutation, from Brazil.
One of the cases was linked to international travel and the other is still under investigation, health officials said. They did not confirm where either had been found.
Concerns have been expressed that vaccines may not be as effective against this strain which was discovered on March 9 after 33 cases were reported in the Philippines.
It has been designated as a variant under study (VUI) rather than a variant of concern like the Manaus strain.
PHE said in a statement, “The variant includes a number of notable mutations, including E484K and N501Y, which are found in several other variants of concern. Public Health England has identified two cases of this variant in England.
“One of the cases is related to international travel and the other is currently under investigation. All appropriate public health interventions are undertaken. ”
It comes as two more cases of the Manaus variant, known as P1, have been discovered in England, PHE has confirmed.
One case was found in the West Midlands and the other in Haringey, London, and both are linked to international travel to Brazil.
PHE said surge testing will be stepped up and area and contact tracing teams are investigating to identify further contacts.
This brings the total number of Manaus cases in the UK to 12, all with links to travel from Brazil.
Additional reports by the PA