Erik Lamela and Japhet Tanganga have returned to light training, but they are unlikely to be ready to play at the bet365 stadium.
Mourinho faces decisions within his squad, but he can choose to keep the backbone of Hugo Lloris, Toby Alderweireld, Pierre-Emile Hojbjerg and Harry Kane in place – and make changes around her.
Matt Doherty is expected to start, especially after Serge Aurier’s horror show on Sunday, while Ben Davies, Harry Winks and Davinson Sanchez will also watch the minutes.
Gareth Bale can be expected to start after playing a half against Leicester, while Steven Bergwijn could also return to the top three.
Dele Alli will also be desperate for a run, but it seems unlikely that he will go straight into the XI after being left out of Mourinho’s nine-man bench against the Foxes.
Prediction of Tottenham XI (4-2-3-1): Lloris; Doherty, Sanchez, Alderweireld, Davies; Hojbjerg, winks; Bergwijn, Bale, Lucas; Kane.
Wednesday 23 December, 17h30, Sky Sports
The Tottenham team of: Lloris, Hart, Gazzaniga, Whiteman, Doherty, Aurier, Rodon, Alderweireld, Davies, Reguilon, Dier, Sanchez, Winks, Sissoko, Hojbjerg, Dele, Clarke, Lo Celso, Ndombele, Bale, Lucas, Son, Bergwijn, Vinicius, Kane .
Doubts about injuries: Lo Celso, Lamela, Tanganga
Last meeting: Stoke 1-2 Tottenham