There were large outbreaks of the virus in student quarters and university housing in September and early October.
At the time, areas south of Manchester city center had some of the highest rates in the country.
But now one of the old hot spots, University North & Whitworth Street, has the lowest rate in town.
At University North & Whitworth Street, there were fewer than three cases in the seven days leading up to November 24, according to the most recent data available.
At its peak, the region had 238 confirmed positive tests in the week ending September 29, with the virus spreading rapidly through the student body.
Its infection rate at the time reached 2,201.1 per 100,000 inhabitants.
Only Poynton East and Poynton West, on the Stockport – Cheshire border, recorded fewer than three cases in the same week.
Meanwhile, the area referred to in government statistics as “Hulme and the University” recorded just 22 cases during the week ending November 24.
The district’s current infection rate is also well below the national average for England of 167.4 per 100,000 population.
Hulme and University’s rate is currently 150.2 per 100,000 population.
The turnover rate there fell from a high of 1,017.3 cases per 100,000 population on September 29, when there were 149 cases.
The data released by the government relates to areas known as Middle Super Output Areas (MSOA), which are statistical units with between 5,000 and 15,000 inhabitants.
At one point on October 3, students and people aged 17-21 accounted for 55% of Covid-19 cases in Manchester.
Public health chiefs said it was an “expected increase” as thousands of students descended on the city for the fall term.
Last month, they said the epidemics that hit the Birley and Cambridge Halls of the Metropolitan University of Manchester, as well as the Fallowfield campus of the University of Manchester, are under control.
At Fallowfield Central – once the country’s Covid hotspot – there were 422 cases in the week ending October 6, up from 19 cases in the week ending November 24.
The infection rate fell from 3,532 per 100,000 population to 159.0.
The huge drop in cases among young people has been attributed to a number of swift actions taken by Manchester City Council and universities.
All teaching at the University of Manchester and MMU went fully online as of October 6 following a decision by the city’s public health department, alongside Public Health England.
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