The Premier League champions will look to preserve an unbeaten home run that is approaching its four-year anniversary.
They will have to do it without several first-team stars with Diogo Jota the last long-absent.
But heading into the competition, Mourinho, who has nearly a top-performing squad, is not convinced Liverpool’s resources are really being tested.
Virgil van Dijk and Joe Gomez will be sidelined for months, leaving Klopp’s defensive options tested.
But other than that, the Tottenham boss feels like the Reds boss has a wealth of talent to choose from.
“Every club has injuries from time to time. Liverpool have a big injury, which is Van Dijk, ”Mourinho said.
“The injuries are normal. James Milner is injured, [Erik] Lamela is injured. ”
“I think Alisson is not injured. [Trent] Alexander-Arnold is not injured. Matip, I think he’s going to play. Fabinho is not injured. [Andrew] Robertson is not injured. [Jordan] Henderson is not injured. [Georginio] Wijnaldum is not injured. [Mohamed] Salah is not hurt, [Roberto] Firmino is not injured, [Sadio] Mane is not injured.
“Van Dijk is injured and Van Dijk is of course a very good player. But give me the list of Liverpool’s injuries and compare it to who are the best Liverpool team. ”
Klopp looks set to play Fabinho and Nathaniel Phillips as a fullback with Joel Matip unable to shake off the injury he suffered at Fulham.
Curtis Jones continues in the usual three-way midfield.
Tottenham, meanwhile, will continue with their now established form and staff.
Steven Bergwijn will complete the attacking trio in what is expected to be the same XI of the draw at Crystal Palace on Sunday.
Liverpool Prévue Composition: Alisson, Alexander-Arnold, Phillips, Fabinho, Robertson, Jones, Henderson, Wijnaldum, Mane, Firmino, Salah
Scheduled lineup for Tottenham: Lloris, Aurier, Dier, Alderweireld, Reguilon, Sissoko, Hojbjerg, Ndombele, Bergwijn, Kane, Son