The stylized image shows them in front of a house of Wendy which is in their California home.
The design was revealed after the card was sent to the Mayhew Animal Welfare Charity, which Meghan is supporting as a patron.
Mayhew tweeted the image with a thank you for an undisclosed donation made by the Sussexes.
The image is from a photograph taken by Meghan’s mother Doria Ragland.
A small Christmas tree in the photo is decorated with ornaments selected by the couple’s 19-month-old son.
Meghan’s message in the card read: ‘This year as a family we have donated to several charities with you in mind.
“From a local California organization that helps families get out of homelessness, to two of our UK patronages: one supporting animal and community welfare, and the other, a memorial fund for a cherished friend who helps educate children and fight poverty in Uganda, we honored their work on behalf of all of us. ”
Mayhew said on his website that the money would help him “withstand the continued impact of the COVID-19[feminine[feminine pandemic and allow us to reach animals and people in difficulty ”.
We are delighted to receive wonderful Christmas greetings from our Patroness, The Duchess of Sussex, who has also made a personal donation, helping dogs, cats and our community. 💜 From all of us at Mayhew, thank you and Merry Christmas. 🎄🐶🐱
Find out more! 👉 https://t.co/5o2RHLveRM pic.twitter.com/uBV19F6Odt
– Mayhew 🐶🐱 (@themayhew) December 23, 2020
It was announced last week that the Duke and Duchess have signed an agreement with Spotify to host and produce podcasts to highlight ‘different perspectives and voices’.
Harry and Meghan’s production company Archewell Audio has partnered with the streaming service for an undisclosed fee.
It is estimated at around $ 25million (£ 18million) for their charity Archewell.
A spokesperson for the Sussexes said of the card: “The original photo of the family was taken at their home earlier this month by the Duchess’s mother.
“The small Christmas tree, including the homemade ornaments and other decorations, has been selected by Archie, and the tree will be replanted after the holidays. ”
Caroline Yates, Managing Director of Mayhew, said: “We are delighted to have the Duchess of Sussex as our sponsor, and she has shone a spotlight on our community animal welfare work over the past two years.
“We were especially honored to recently receive a personal donation from the Duke and Duchess, which will allow us to help even more cats, dogs and pet owners in need during this difficult winter time.