It’s the biggest jump on a Friday since 414 deaths on May 8.
By comparison, recent Friday tolls were 270 on November 6, 202 on October 30, 167 on October 23, 98 on October 16, and 64 on October 9.
The lowest number of hospital deaths announced on a Friday was five on August 21, while the highest total was 953 on April 10 when the UK was at the initial peak of the pandemic.
The new figures were released as the death toll involving health and primary care workers rose to 200, and government scientists have warned that infections would likely rise again in December if lockdowns are lifted everywhere.
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The government’s official record in all settings, including nursing homes and private homes, has exceeded 50,000.
NHS England has announced 246 deaths, bringing the total number of confirmed deaths in hospitals across England to 35,886.
The victims were aged 26 to 100, and all but five (aged 69 to 89) had known underlying health issues.
In Scotland, the death toll rose from 56 to 3,244.
Wales reported 29 more deaths to bring its total to 2,171.
Northern Ireland’s death toll stands at 836 after 11 more deaths.
At least 200 health and primary care workers have now died after contracting coronavirus, it was confirmed on Friday.
The list of health and social service workers includes those who held positions shortly before their death and where they were likely to come into contact with patients.
The most recent victim was the consultant anesthesiologist Dr Krishnan Subramanian, who died on Thursday.
“Quiet and dedicated,” Dr Subramanian, who was in his 40s, worked at the Royal Derby Hospital.
He was treated at Glenfield Hospital in Leicester before his death.
Meanwhile, the UK coronavirus (R) breeding number has dropped slightly to between 1 and 1.2 across the UK, but deaths will continue to rise, government scientists say.
Analysis by the Scientific Advisory Group for Emergencies (Sage) suggests that infections are likely to rise again in December if lockdowns are lifted everywhere.
He suggests that local restrictions will be needed in some areas in the weeks leading up to Christmas.
Sage has warned that the virus is still spreading and deaths and demand for health care will continue unless R drops below 1 for an extended period.
He said the number of new infections was increasing 1% to 3% every day.
Over the past few weeks, he has put the R between 1.1 and 1.3.
If the R-value is greater than one, the Covid-19 epidemic continues to grow, but if it is less than one, it shows that the epidemic is on the decline.
Separate documents from Sage released on Friday indicate that the national outbreak is still at a “high and controlled” stage.
If this remains the case, or if the epidemic returns to current levels after the national lockdown is lifted on December 2, Sage said there was “little or no opportunity to relax social distancing rules. at Christmas”.
The official number of R breeders is always greater than 1 as infections continue to increase in the elderly.
For England, the R is slightly higher between 1.1 and 1.2, down from a range of 1.1-1.3 the week before.
This suggests that R could have fallen below 1 in Wales and Scotland.