Jurgen Klopp’s side will be without Virgil van Dijk, while City’s defensive problems have also been talked about a lot.
All of this means that Owen expects goals, but cannot divide the two teams.
He told BetVictor: “I can’t wait for this one! The top two from last season are battling it out in what I expect to be an exciting meeting at the Etihad.
“Man City may be 10 in the table, but they come into that area having won 8 of their last 9 Premier League games at home.
All the latest transfer news and big stories will arrive straight to your inbox. You won’t miss a thing.
To subscribe, put your email at the top of this article or follow the instructions at this link.
“While Liverpool lost Virgil van Dijk to injury and Manchester City still haven’t worked out their issues at the back, I can see goals in this one.
“There have been over 2.5 goals in 9 of Liverpool’s last 10 league games, and I can see that trend continues here with both teams playing a draw. ”
The Merseyside vs Manchester theme continues as Everton entertains United at Goodison Park.
Ole Gunnar Solskjaer’s side have suffered back-to-back defeats at home and in Europe.
But with both teams stuttering, Owen reckons the points will be split.
He said: “Everton’s good start to the Premier League season has taken a few hits in recent weeks. It’s now been 3 matches since Everton’s last win.
“Key absences in their starting XI have taken their toll, however, Lucas Digne is coming back from suspension here and there is hope that James Rodriguez will be part of the squad.
“United suffer a miserable fate. They had little time to prepare for this, just returning home after an embarrassing defeat in Istanbul.
“Ole Gunnar Solkjaer will demand nothing more than 3 points here and needs a big performance from his players.
“It should be noted that United have won their last 6 Premier League away matches. That said, there isn’t much between these two at the moment, and I think they have to settle for a draw. ”
Chelsea are in the middle of a healthy unbeaten run and appear to have resolved their defensive issues.
They travel north to Sheffield United, where Owen expects them to collect all three points.
He said: “Chelsea appear to have stabilized after their shaky start. Much of this is due to both Edouard Mendy and Thiago Silva having the desired effect at the back for Frank Lampard.
“Unbeaten in 10 games, they’ve won their last three games and for the first time in a decade, they’ve had five consecutive white sheets.
“Sheffield United are improving. The courageous performances against Liverpool and Manchester City earned applause from Steel City, but if the Blues shoot here I can see them running out of comfortable winners. ”
Owen also believes Arsenal will enjoy a comfortable victory over Aston Villa, which saw their initial momentum cut short.
Dean Smith’s side lost two on the rebound which could soon become three on their trip to the Emirates.
Arsenal had an excellent victory at Old Trafford last week, ”said Owen.
“Mikel Arteta has set his stand up perfectly, and the Gunners are hoping to bring that momentum into it.
It will be another tough challenge for Villa, and I expect Arsenal to have the tail. I prefer the good vibes to continue for the home side with a comfortable win against the Villains. ”
The former Liverpool and Newcastle striker also backed Leeds, West Ham and Tottenham to collect all three points.
Will Man City beat Liverpool at the Etihad on Sunday? Give your opinion here.
* Sign up for the Mirror Football email here for the latest news and transfer gossip