Witnesses said the pre-dawn strikes hit targets in Gaza City and the towns of Rafah and Khan Younis in southern Gaza, where flames and plumes of smoke could be seen rising from some sites.
There was no immediate claim of responsibility by any of the military groups in Gaza.
Hamas spokesman Fawzi Barhoum blamed the new escalation on Israel.
“The Israeli occupation is primarily responsible for everything that happens in Gaza as it continues to block it and carry out attacks. The resistance only acts in self-defense, ”Barhoum said.
The IDF said on Twitter that it struck targets belonging to Hamas, the group that rules Gaza, in response to a suspected rocket attack launched from the Palestinian enclave.
He said the Israeli Air Force struck two rocket manufacturing sites, a military compound and “underground infrastructure”.
In response to a rocket fired from Gaza into Israel earlier this evening, the Israeli Air Force struck Hamas military targets in Gaza, including:
🎯 2 rocket ammunition manufacturing sites
🎯 underground infrastructure
🎯 a military complex
We hold Hamas responsible.
– Israel Defense Forces (@IDF) November 22, 2020
According to the military, a rocket was fired at Israel from the Gaza Strip on Saturday evening, shortly after warning sirens sounded in the southern Israeli town of Ashkelon.
The military statement gave no further details, but Israeli media said the projectile landed on open ground.
The last reported fire from the Hamas-ruled Palestinian enclave came after two rockets were fired from the coastal strip into Israel in the early hours of last Sunday.
There were no casualties or damage in this attack. Israel retaliated with fighter jets, helicopters and tanks, hitting what the military said were Hamas targets.
There was no claim of responsibility for the rocket attacks on November 15, but Israel holds Hamas responsible for all attacks emanating from Gaza, including those claimed by other groups of fighters based in the Gaza Strip. enclave.
Deadly outbreak of violence
The impoverished and densely populated Gaza Strip has been subjected to a crippling Egyptian-Israeli blockade since 2007, when Hamas took control of the strip.
Hamas and Israel reached an agreement in late September to end hostilities, although the attacks continue.
The ceasefire followed a deadly surge in violence and was expected to see Israel authorize new development projects, including an industrial zone and a hospital.
Hamas accused Israel of failing to fully respect the agreement. Israel, which considers Hamas a “terrorist” organization, avoids direct negotiations and has never publicly acknowledged the truce.
Israel has launched three offensives against the Gaza Strip since 2008, and there have been numerous outbreaks.
Palestinian analysts say the cross-border shootings from Gaza are often used as a negotiating tool to get the go-ahead from Israel for the entry of Qatari financial aid into the territory.