The agreement with the Top 14 means that Galthie will be without captain Charles Ollivon as well as Antoine Dupont, Virimi Vakatawa, Gregory Alldritt, Gael Fickou, Baptiste Serin and Teddy Thomas among others.
“We just have to go ahead and manage what we have,” Galthie said on Sunday.
“You can’t ask the players to come in and go and come back.
“It’s too difficult for a player. Club rugby and international rugby are two different things.
“We are happy with what we have in an environment that is not ideal. ”
France will also be deprived of the semi-first choice Romain Ntamack, excluded due to injury.
The injuries and the deal with the Top 14 mean France will be deprived of the entire starting XV that beat England at the Six Nations in February.
Eddie Jones’ England won’t have a similar problem as they have a deal with the Gallagher Premiership sides which means the players are available for additional internationals this year.
“England is a nation that doesn’t lose much and will play with its best team. They are probably the best team in the world at the moment since South Africa has not played, ”added Galthie.