Summer signings Bale and Vinicius start in attack with Lucas Moura. Erik Lamela is also returning, while Dele Alli, Harry Kane and Heung-min Son are all on the bench.
Eric Dier is out after sitting down in training on Wednesday morning. Dier was absent for the 3-3 draw with West Ham on Sunday due to a hamstring problem suffered in England and he is still not fit enough to return, leaving Jose Mourinho short of a center-back.
Japhet Tanganga (thigh) is also sidelined and new signing Joe Rodon is not eligible for the Europa League.
In a boost to the Spurs manager, Giovani Lo Celso is back from injury and is on the bench.
Tottenham XI: Hart, Doherty, Sanchez, Davies (C), Reguilon, Hojbjerg, Winks, Lamela, Bale, Lucas, Vinicius
Submarines: Lloris, Austin, Aurier, Alderweireld, Sissoko, Ndombele, Clarke, Lo Celso, Dele, Bergwijn, Son, Kane