The reporter was embroiled in a series of harrowing exchanges with the president as she pushed for answers on his response to the coronavirus, white supremacy and QAnon.
Australia-born Ms Guthrie is married to former Democratic political aide Michael Feldman, with whom she has two children.
Mr. Feldman served as Al Gore’s traveling chief of staff during the 2000 election campaign and is the founding partner and managing director of a communications and advocacy firm.
He founded The Glover Park Group with his fellow campaign advisers Gore Carter Eskew and Chip Smith, as well as former White House press secretary Joe Lockhart.
Ms Guthrie has worked for NBC in a variety of roles since 2007, when she joined as a legal analyst after serving as a national correspondent for CourtTV.
The broadcaster covered Sarah Palin’s vice presidential campaign in 2008 before being named NBC News’ White House correspondent later that year.
After fulfilling the role of co-host on the Today’s show she then became a full time host at 9 a.m.
But she was catapulted to national fame when she co-hosted the show alongside Matt Lauer in 2012 following the acrimonious departure of Ann Curry.
When Mr Lauer was forced to resign in 2017 amid allegations of sexual misconduct, she and Hoda Kotb became hosts of the Today’s show.
Ms Guthrie held back tears live as she announced Mr Lauer’s departure, calling the allegations against him “shocking and appalling”.