In footage of the incident, two men can be seen running down the aisle towards a scuffle in the front of the plane between a woman and a man.
Ryanair staff can be seen desperately trying to separate the screaming and punching passengers.
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The two men who ran forward return to their seats as a flight attendant forces the woman out of the front of the plane.
Police then board the flight and evacuate a man who was allegedly assaulted by a woman, along with his two male friends.
They then questioned the passengers about the incident.
Witnesses said the brawl began after a man threatened a female passenger.
The video shows the woman yelling at a man as he sits down before she appears to punch him.
Then two men rushed from the back of the plane into the fight.
The two men are believed to know the woman as well as another passenger who can be heard shouting their names, telling them to stop and “come home”.
The Ryanair flight had taken off from Malaga and had just arrived at Manchester Airport on Monday evening when the fight started.
A man can be seen at the end of the video clip asking a nearby passenger “What are you wearing, bum?” Listen, do you want to go? Before a woman held him back.
The passenger who filmed the fight said: “It was really disgusting.
“We were about 20 minutes from landing and I’m not sure what happened, but the woman in the black sweater started to pounce on this guy in a big way.
“It wasn’t a light slap or anything, she fit him for leather.”
“Suddenly three or four people ran to the front and got involved – there were only fists flying everywhere!
“Some of them were really big guys and the Ryanair staff eventually split them up but at one point they had completely lost control of the situation.
“The staff made the woman sit behind us, so I asked her what had happened and she said that a man had threatened to kill her.
“The police got on board and no one was able to get off until they checked who was involved in the fight, so we showed an officer our video footage so he could see who he was. was acting.
“The police got everyone involved in the fight to keep him on the plane and we heard an officer tell Ryanair staff that they might need to use tasers. ”
A Ryanair spokesperson said: “The crew of this Malaga-Manchester flight (October 26) requested police assistance on arrival after several passengers became disruptive shortly before arrival.
“It’s now a local police matter. ”
Greater Manchester Police have been contacted for comment.