With talisman Virgil van Dijk absent for several months with an anterior cruciate ligament injury – ruled out with the Premier League champions team on Tuesday until January – Jurgen Klopp has to shuffle his bag.
This means Liverpool are expected to line up with Joe Gomez and midfielder Fabinho in central defense.
Adrian will also continue to replace Alisson in goal, although the Brazilian is set to return to action following a shoulder injury.
Thiago Alcantara, who injured his knee in a tackle that saw Richarlison of Everton sent off on Saturday in the Merseyside derby, has also not trained and is unlikely to play, which means that Jordan Henderson and Naby Keita will start alongside Gini Wijnaldum.
Liverpool XI set to face Ajax (4-3-3): Adrian; Alexander-Arnold, Fabinho, Gomez, Robertson, Keita, Henderson, Wijnaldum; Salah, Firmino, Mane