Much will depend on the physical form of Thiago Alcantara, with Jurgen Klopp giving the Spaniard every chance to prove he is ready.
So suppose he succeeds. And that means his Iberian colleague is heading for the bench.
To be fair, the Liverpool squad choose themselves. The back five is the one that ended against FC Midtjylland.
Thiago can join Jordan Henderson and Gini Wijnaldum in midfield.
And the first three are, well, the first three.
My team (4-3-3): Alisson; Alexander-Arnold, R Williams, Gomez, Robertson; Henderson, Thiago, Wijnaldum; Salah, Firmino, Mane
“Klopp can go rogue with a change of formation as Thiago starts for Liverpool”
Connor Dunn: I’m throwing away the rulebook and going crazy with my team picker this week.
As we know Liverpool are in the midst of an injury crisis on defense and for me going all the way on offense and being careful trying to mercilessly beat West Ham is the best option.
I will therefore choose a relatively fluid and hard-working 3-5-2 training.
Now Alisson starts in the goal but my back three is made up of Jordan Henderson on the right, Joe Gomez in the middle and James Milner on the left.
On each flank of my midfield five are Trent Alexander-Arnold and Andy Robertson.
We know both players have an amazing motor and therefore can move up and down as they normally do to help defense and tie up the attack, while Henderson and Milner have both proven their versatility and will have the skill to play. at the heart of a back line.
In the middle of the park are Gini Wijnaldum and Thiago Alcantara. Jurgen Klopp refused to exclude Thiago from the game and so he’s starting to display a range of assists that will help the Reds protect their goal.
Willing and fit Diogo Jota will join them in the middle, although he’ll line up right in front of them in an almost 3-4-1-2 setup but not as stiff.
Leading the way, Mohamed Salah and Sadio Mane should hopefully wreak havoc.
My team (3-5-2): Alisson; Henderson, Gomez, Milner; Alexander-Arnold, Wijnaldum, Jota, Thiago, Robertson; Faux, Mane.
“Rhys Williams gets nod after news of West Ham injury”
Sean Bradbury: Well, this one is going to be interesting. Let’s do it the easiest way.
With Atalanta and Manchester City on the horizon, I can’t see all the usual top three starting.
Mohamed Salah can rest after playing every minute in the Premier League so far.
I would go with Roberto Firmino in the middle, Diogo Jota on the left and Sadio Mane in his old location on the right.
In midfield, Gini Wijnaldum starts in the deepest role. Jordan Henderson is ahead of him.
And if Thiago Alcantara is fit enough for an hour of football, I would play the new signing to build the pace before the two crunch clashes.
Then at the back …
Alisson is of course in goal, with Trent Alexander-Arnold and Andy Robertson on the flanks. Joe Gomez is the senior man in the middle.
If Michail Antonio were available for West Ham, I would have been tempted to go with Nat Phillips based on a bit more experience to try and deal with the fit striker.
But instead, Rhys Williams gets the nod to try to impress again after his midweek performance.
My team (4-3-3): Alisson; Alexander-Arnold, Gomez, R Williams, Robertson; Wijnaldum, Henderson, Thiago; Mane, Firmino, Jota.
“Klopp could have a chance for Man City trial”
Peter Harris: It feels like a dress rehearsal of how Jurgen Klopp will set up his squad against Manchester City the following weekend, even though his side will have to travel to Italy before venturing to the Etihad.
Is the Reds manager calling on another of his reliable midfielders to fill that defensive void left by Virgil van Dijk and now Fabinho? Or does he trust one of his young defenders?
He is hopeful beyond all hope that Joel Matip has gotten into shape before the champions move on to meet Pep Guardiola’s men, but Rhys Williams is a defender by trade and hasn’t looked out of place during his Champions League appearances.
There are also midfield injuries – so defender Williams should be tasked with defending. He may have to do a lot of this over the next few weeks.
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Jordan Henderson, who should be an option at center-back, will be needed in midfield alongside Gini Wijnaldum as the 4-2-3-1 formation is used again. Thiago narrowly misses a starting place. The last thing Liverpool need is to push anyone away from an injury and make the situation worse.
Roberto Firmino is the striker to take on more of an attacking midfielder role with Sadio Mane and Diogo Jota resting on the wings. Mohamed Salah will take the place of a striker with the idea that such a formidable front line will overwhelm the Hammers.
My team (4-2-3-1): Alisson; Alexander-Arnold, Gomez, R Williams, Robertson; Henderson, Wijnaldum; Firmino, Mane, Jota; Salah.