The match also gives the opportunity to quickly find his former club for Cavani, who left the Parisians when his contract expired last summer.
The Uruguayan, who is the top scorer in PSG history, signed a first one-year contract with United on the deadline day on a free transfer after his release from the French champions.
However, he was unable to make his debut on Saturday’s trip to the North East as his period of isolation after arriving in the UK did not end until Sunday.
Cavani is now in the running to make his bow for United against his former side, but Mbappe has made it clear that their friendship will be put aside for the 90 minutes.
“Not at all, he’s in a different team now,” the Frenchman told TF1 when asked if it would be strange to run into his former teammate.
“I wish him the best. We will play against him and try to beat him. ”
Following their trip to Paris, United will face RB Leipzig at Old Trafford before flying to Turkey to face Istanbul Basaksehir.