The Sheffield United striker led the line superbly in Ireland’s shootout loss to Slovakia in their Euro 2020 qualifying semi-final.
McGoldrick was taken out towards the end of the first overtime period in Bratislava, having created a number of scoring opportunities.
He could only watch Ireland lose 4-2 on penalties following a goalless draw, missing a final showdown with Northern Ireland and the chance to play in a third successive European Championship , where Dublin will be one of the host cities.
McGoldrick’s absence for the UEFA Nations League double header is yet another blow to shy Stephen Kenny’s side, who have scored once in three games at the head.
Kenny will also take a late decision over Crystal Palace midfielder James McCarthy, who fell while gripping his thigh on Thursday.
“James McCarthy isn’t too bad, but we’ll have to wait and see how he is compared to how close he is to tomorrow’s game, so he’s doubtful,” Kenny said.
“But he didn’t get any tears or anything like that. The scan went well, there is good news about his scan. “
Kenny called Sean Maguire and Daryl Horgan on Friday in place of Aaron Connolly and Adam Idah, who were taken out minutes before the kick-off against Slovakia after being deemed to have been in close contact with a staff member of the backstage who had tested positive. for the coronavirus.
A late appeal for both players to be allowed to play was dismissed and Kenny confirmed Brighton winger Connolly would have started.
“There is no doubt that it was extremely disappointing, extremely disappointing. We are very, very disappointed about this.
“Aaron was selected in the squad and Adam would have been a good offensive option for us too, and to find out on game day, then a bit of a saga as the possibility existed of a call and so on in the situation .
“It was not a good preparation on the day of the game because we were having discussions about it and its impact rather than the game itself.
“But listen, there’s nothing we can do about it. The players were excellent that night. There was no guarantee if we had both players. ”
Ireland sit third in their Nations League group after drawing with Bulgaria and losing to Finland in their opening two matches.