Dr Anthony Fauci will also be honored during the virtual celebration.
Cardinal Timothy Dolan will also celebrate the day with a mass at St. Patrick’s Cathedral.
In a typical year, the annual Columbus Day Parade in New York City is the largest celebration of Italian-American heritage and culture in the United States.
Meanwhile, Governor Cuomo will also celebrate Columbus Day by unveiling a statue of Italian religious figure, Mother Cabrini, on Monday in Battery Park City.
Mother Frances Cabrini was an Italian-American Catholic nun, who helped many Italians immigrate to the United States.
She was canonized in 1946 as the first American saint and is the patron saint of immigrants.
The governor announced last year that a monument would be dedicated in his honor, with state funds.
It follows controversy when Mayor Bill de Blasio and First Lady Chirlane McCray were criticized that Mother Cabrini had not been chosen for a new series of city statues honoring women.
This despite Cabrini winning the vote in a public poll.
The snub has even been described as “racist” by some Italian defenders.
Cuomo said Mayor de Blasio and City Council Chairman Corey Johnson were invited to the unveiling.