Running back Jeff Wilson will be injured later this week with a sprained high left ankle, Shanahan said. Any player who switches to IR must miss at least three games.
Wide receiver and back man Richie James is day to day with a sprained ankle.
Shanahan said he hopes running back Tevin Coleman (knee), nickel back K’Waun Williams (knee) and safeties Jimmie Ward (quadriceps) and Jaquiski Tartt (groin) will be available to play against the Seahawks. He said those decisions will likely not be known until later in the week after watching them practice.
Samuel suffered a hamstring injury in the fourth quarter of the 49ers’ 33-6 win over the New England Patriots on Sunday.
The receiver missed the first three games of the 49ers season after starting the season on the injured reserve while recovering from surgery to repair a broken left foot. He has 16 catches for 185 yards and a touchdown, while gaining 14 yards on six rushing attempts.
The 49ers have 14 players in the injured reserve, although nickel back K’Waun Williams should be allowed to return to practice this week after missing three games with a sprained knee.
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Wilson, a third-year pro, had his best game in the NFL on Sunday with 112 yards and three touchdowns in 17 carries. He sustained a left ankle injury on a 7-yard touchdown midway through the third quarter. After leaving the field on his own, he was taken to the 49ers locker room on a cart.
James has appeared in three games after missing four weeks with a hamstring injury. He’s yet to catch a pass, and he’s averaging 10 yards on two punt returns and 20.0 yards on three kickoff returns.
Wilson stepped into the role of running back for the 49ers on Sunday against the Patriots. Raheem Mostert (ankle) and Tevin Coleman (knee) are on the injured reserve. Mostert will miss at least two more games. Coleman hasn’t played since the 49ers won in Week 2 over the New York Jets.
The only two healthy carriers for the 49ers are Jerick McKinnon and undrafted rookie JaMycal Hasty.
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McKinnon is the 49ers’ second lead runner with 210 yards and three touchdowns on 44 carries. He has a rushing average of 4.8 yards. McKinnon added 17 receptions for 117 yards and a touchdown.
Hasty gained 103 yards on 20 attempts (5.2 on average). It also has two holds for 25 meters.
The 49ers could promote running back Austin Walter to the practice team. Walter spent 2019 training camp with the 49ers as Rice’s undrafted rookie.