Nice to meet you
Dick York had to retire from the role of Darrin Stephens in the fifth season of this ABC sitcom amid back problems caused by a previous injury. Dick Sargent has filled the role for the last three seasons of the ABC show.
Kevin can wait
This sitcom controversially killed Erinn Hayes’ character between seasons 1 and 2, replacing her with a new female lead role played by former Kevin James King of queens costar, Leah Remini. CBS, however, canceled the show at the end of Season 2.
In May 2018, Clayne Crawford was fired from the cast of this Fox procedure after alleged bad behavior on set. In his absence, Seann William Scott starred with Damon Wayans in what ultimately became the series’ third and final season.
Jon Lovitz has joined the cast of this NBC sitcom for its fifth and final season to help fill the void left by the death of his friend and former Saturday Night Live costar Phil Hartman.
Rob Morrow left this Emmy-winning CBS drama amid a contract dispute midway through its fifth and final season. He was struck off the show and Paul Provenza joined the cast as his replacement, but the series ended 15 episodes later.
Steve Carell left this beloved NBC comedy in its seventh season, and the management of the Scranton branch of Dunder Mifflin Paper Company went to characters played by James Spader, Catherine Tate, Kathy Bates and Will Ferrell. Even with such talent, the show slipped in ratings and ended two seasons later.
By the time the ninth season of this NBC-turned-ABC comedy premiered, Zach Braff and Sarah Chalke had fallen to recurring status, and Judy Reyes had left the series. Eliza Coupe, Kerry Bishé, Michael Mosley and Dave Franco fleshed out the Scrubs thrown in their place, but ABC canceled the show at the end of the season.
Nicole Beharie’s Abbie Mills was killed in this Fox drama amid the actress’ health issues at the end of Season 3. The producers brought in Janina Gavankar as the new female star for Season 4, which ended by being the show’s final season.
This 70s show
This Fox sitcom lost star Topher Grace at the end of its seventh season, and for the eighth and final season, the producers brought in Josh Meyers – Seth’s younger brother! – in an effort to replace it.
Two new agents – Robert Patrick’s John Doggett and Annabeth Gish’s Monica Reyes – began investigating the X-Files in this Fox drama after David Duchovny bailed out half of season 8 and most of season 9. (Mulder and Scully were back together in the show’s two rebirth seasons, however.)