The 49ers removed wide receiver Deebo Samuel from the non-football injury roster before the reduction to 53 players because they believed he would be ready to play at some point in the first six weeks of the season.
On Saturday, the team announced that Samuel will not play for at least the first three weeks of the season. Samuel, who is returning from a broken foot suffered during offseason training, has been placed on the injured reserve and cannot be activated until he is on the roster for three weeks.
The 49ers called Brandon Aiyuk questionable in Friday’s injury report due to a hamstring injury. Kendrick Bourne, Trent Taylor, Dante Pettis and Richie James are expected to play wide receiver.
In addition to Samuel’s move, the Niners also announced that they have promoted center Hroniss Grasu and cornerback Dontae Johnson from the practice squad. Center Ben Garland is considered questionable for Sunday’s game against the Cardinals and cornerback Jason Verrett has been ruled out.