The debate will be different from others in recent years due to the coronavirus pandemic. The two presidential candidates have been instructed not to shake hands and the audience for the debate will be very limited.
The debate can also be particularly controversial, given the attacks the two campaigns have launched against each other in recent weeks.
In the hours leading up to the debate, the Trump campaign peddled baseless claims that Biden might be taking drugs or using a headset to improve his performance tonight.
The Biden campaign responded by accusing the Trump team of trying to distract from the substance of the debate out of concern about the president’s performance.
Nominees can repeat these attacks when they take the stage, so moderator Chris Wallace of Fox News will likely have their work cut out for them.
Contestants will take the stage in just over an hour, so stay tuned.