Scotland has recorded 486 new positive cases of the coronavirus – the highest daily total since the start of the epidemic.
Prime Minister Nicola Sturgeon said the numbers were concerning and highlighted why new restrictions had been imposed.
But she said it was important to remember that many more people are tested now than at the peak of the outbreak earlier this year.
Ms Sturgeon said 224 of the new cases were in Greater Glasgow and Clyde, 107 in Lanarkshire and 57 in Lothian.
The number of positive tests was 103 higher than the figure recorded on Tuesday, bringing the total number of cases in Scotland to 25,495.
Ms Sturgeon said the numbers in the Greater Glasgow and Clyde area included a “significant” outbreak at the University of Glasgow.
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People across Scotland have been banned from visiting other people’s homes from today, with Ms Sturgeon warning that the virus is likely to ‘get out of hand’ unless urgent action is taken.
The move means Scotland will have tighter coronavirus restrictions than England – where people can still meet in groups of up to six people in a house.
Scotland, like England, will also impose a 10 p.m. curfew on pubs and restaurants from Friday – which the trade says could cost jobs and force some premises to shut down completely.
Speaking in her daily briefing on Wednesday, the prime minister said: “The total number of positive cases reported yesterday was 486 – this is the highest number of positive cases we have ever recorded in a single day.
“You have to remember that many more people are tested today than was the case in the spring.
“Nonetheless, today’s number represents 7.8% of those newly tested. This is obviously a real cause for concern, but it also underlines why we took very decisive and very tough measures yesterday. “