Marika Bret said her guards, who protected her for nearly five years, received the threats on September 14.
She accused “a level of hallucinating hatred around Charlie Hebdo”.
The magazine was the target of a deadly terrorist attack in January 2015, in which 12 people were killed, after publishing caricatures of the Prophet Muhammad.
The attacks sparked a wave of jihadist strikes across France.
Earlier this month, the magazine reposted the controversial cartoons, before 14 people on trial on charges of aiding the two gunmen in the attack.
Speaking to Le Point magazine, Ms Bret said: “I have had 10 minutes to do my business and leave my home, 10 minutes to give up part of my life… I will not be coming home”.
She added that the threats resumed with the start of the trial and the republication of the Prophet Muhammad cartoons earlier this month.
The cover of the Charlie Hebdo issue published in early September featured the 12 original cartoons of the Prophet Muhammad, which were published in a Danish newspaper before appearing in Charlie Hebdo.
One of the cartoons shows the prophet wearing a bomb instead of a turban. The French title reads “Tout ça pour ça” (“Tout ça pour ça”).
In its editorial, the magazine said it had been asked many times to continue printing caricatures of the prophet since the 2015 murders.
“We have always refused to do it, not because it is forbidden – the law allows us to do it – but because there was a need for a good reason to do it, a reason which makes sense and which brings something to the debate. , ”It said.
“To reproduce these cartoons in the week when the trial of the terrorist attacks of January 2015 begins seemed essential to us. “