Espinal, 25, was acquired from the Boston Red Sox in 2018 in exchange for Steve Pearce.
He made his major league debut in 2020. In 11 beats in five games, Espinal had a hit and added a run and stolen base.
Waguespack, 26, was also acquired in 2018 in Cleveland as part of a deal to Josh Donaldson.
He’s made three appearances this season, allowing two hits in four innings, walking three and striking out four.
The Blue Jays (4-5) end their three-game streak with the Atlanta Braves (8-5) on Wednesday night.