Ramirez took the mound in fifth with Chicago leading 1-0. He pulled Luis Robert out to start, but things went south quickly. After two singles, a steal and a walk, Moncada hit a three-run homer to the right.
Grandal followed with another player in the right-field seats, then Abreu and Jimenez each did a circuit to the left.
Manager Mike Shildt replaced Ramirez with Seth Elledge, and he knocked out Edwin Encarnacion on three straight shots to complete the set.
Ramirez is among the players promoted by the Cardinals following a COVID-19 outbreak that stalled Saint-Louis’ season for 2.5 weeks. The club returned to action on Saturday with a double sweep over Chicago.
Ramirez, a 25-year-old right-hander, parted ways last season between Double-A and Triple-A.
It was the 10th time in major league history that a team has hit four straight home runs. The only other time the White Sox have done so was on August 14, 2008 against Kansas City, when Jim Thome, Paul Konerko, Alexei Ramirez and Juan Uribe hooked up.
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