It was their fourth semi-final loss this season in all competitions and Ole Gunnar Solskjaer admitted he needs to strengthen his squad this summer.
They’ll have to break the bank to land primary target Jadon Sancho – and several players would be on the chopping block as they look to fund a move.
Borussia Dortmund are expecting £ 100million for their star man, Ed Woodward reluctant to spend more than £ 80million.
But they haven’t given up on hopes of making a deal and recent history with Harry Maguire and Bruno Fernandes suggests they may hit asking price later as the deadline approaches.
The Red Devils have to sell to fund a move for Sancho and will consider offers for six players.
It is understood that Chris Smalling, Marcos Rojo, Andreas Pereira, Jesse Lingard, Diogo Dalot and Phil Jones are all for sale at a fair price this summer.
Smalling and Rojo have both spent the year on loan and United are hopeful that deals can be made to make their outings permanent.
Pereira and Lingard have both fallen down the pecking order since January following the arrival of Bruno Fernandes and appear likely to be surplus to requirements.
Jones and Dalot have barely featured as well, with Timothy Fosu-Mensah reintroduced ahead of Dalot in the later stages of the season as a cover for Aaron Wan-Bissaka.
United were knocked out of the Europa League in Sunday night’s semi-final, and club legend Paul Scholes immediately warned Ed Woodward he had to be prepared to spend a lot on top players if they were to win again trophies.
Scholes told BT Sport: “I thought they were really good tonight against a very good Sevilla side, but 15-20 minutes after half-time, with all those chances, you have to score them.
“You talk about quality, talk about spending money on center forwards and wide players.
“You’re talking about hundreds of millions for these players, but it’s the players who win you trophies, the ones who win you medals.
“We know this whole Sancho thing is going on, but they have to start spending the money. If they want to win trophies, they have to start spending money. ”
“OK they created chances tonight but if you think a Sancho is in this team tonight I think United are scoring. “