And he called on ministers to “review the decision as soon as possible”.
Greater Manchester, parts of Lancashire and West Yorkshire were subject to targeted lockdown measures on Friday, following a spike in Covid-19 cases.
But despite this, the guidelines have also been relaxed so that clinically extremely vulnerable people are no longer asked to protect themselves.
Speaking at the Greater Manchester coronavirus press conference, Mr Burnham said the move sent a ‘very broad message and put people in a difficult and unfair situation’.
He added: “It was very unfortunate that we had the announcement and then the armor removal almost within 24 hours.
“What did the people who protected for months in Greater Manchester think?
“They are told there is a new risk and people should stay in their homes, but within hours they are told that everything is fine and that we are going to cut the support you are receiving.
“It just wasn’t right – it was inhumane to be honest and the government shouldn’t have let this happen.
“At a minimum, we should have seen the continuation of protective devices in the restricted areas.
“Honestly, I don’t understand why they didn’t do this.
“There is a lot of worry there.
“I would really ask the government again today, it can’t be right when you ask people to observe extra rules and limit contact with other people, you say… that’s okay. for people who have protected to return to stores.
“I call on the government to end this decision and to review this decision as soon as possible. “