It all started with a first single from Oakland shortstop Marcus Semien. Ohtani went on to post back-to-back walks to Ramon Laureano, Matt Chapman and Matt Olson.
Mark Canha and Robbie Grossman followed with back-to-back singles before Ohtani gave way to Matt Andriese, who induced a double play and a strikeout to limit the damage.
Ohtani, 26, averaged 93 mph on a fastball that can hit triple digits. He hit two hits on two of the six hitters he faced but couldn’t put them away.
The right-hander had a 3.10 ERA with 61 strikeouts in 49 innings before tearing his ulnar collateral ligament in 2018, which led to an 18-month recovery. He was also the Angels designated hitter before returning to his starting pitcher career.