An estimated 400,000 other people aged 30 to 49 have also resigned since April, according to an analysis by the charity Action on Smoking and Health and University College London.
This is believed to be due to the health threat as Covid-19 has serious effects on the respiratory system.
A public health campaign is being launched to encourage more people to quit smoking.
The figures were released to coincide with a new campaign, funded by the Department of Health and Welfare, which hopes to target smokers in regions with the highest smoking rates, such as northeastern England.
Matt Hancock has set a government goal for the UK to become smoke-free by 2030.