Sunday, the new champions continue their victory lap by welcoming Aston Villa, threatened with relegation.
Jurgen Klopp will now consider his options after appointing his strongest team possible for the last two games.
And here we’re looking at the changes the Reds boss could make when his team is next in action.
With Joel Matip likely absent for the season and Dejan Lovren in trouble, Liverpool should have no option but to continue with Joe Gomez and Virgil van Dijk in the center back.
Fabinho could enter the heart of the defense as he did in the second period at City, while it would be a great cry to start with the young Ki-Jana Hoever.
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It is more likely that rotation in full rear positions.
Trent Alexander-Arnold and in particular Andy Robertson seemed overwhelmingly out of the box by the middle of the week and, with Neco Williams and James Milner chipping away, there is room for change.
Liverpool were poor at Etihad but some of the substitutes have no doubt made a positive difference in performance.
No less Naby Keita and Alex Oxlade-Chamberlain, who will both press to start.
Curtis Jones, the teenage midfielder, is still patiently waiting for an opportunity, but it could come from the bench.
Gini Wijnaldum could be one to do, although if Fabinho moves to the center back, a position will become available by default.
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Mohamed Salah aside, the Liverpool frontline failed to shine against City, Sadio Mane missing opportunities and Roberto Firmino far below the beat.
So it might be time for some changes, especially since the Reds have now started a busy schedule to end the season.
Divock Origi and Takumi Minamino would both prefer a chance in the middle while Oxlade-Chamberlain can offer a width to the right.
And could it be time for Harvey Elliott? The youngster will be enthusiastic for a first start in the Premier League. Xherdan Shaqiri, if he is capable, is an alternative.