The Egyptian will not recover in time to appear at the London stadium, so Frédéric Guilbert should again replace.
“Ahmed Elmohamady is gone [against Arsenal] with a hamstring injury so he won’t be in good shape for Sunday, ”Smith said.
“We hope Neil Taylor will be back with the team. He has to train tomorrow and he will do a bit of sprinting. I hope he will be back in the team.
Elmohamady has played a key role in Villa revival in recent weeks with seven points in matches against Crystal Palace, Everton and Arsenal that took the club out of the relegation zone.
And as long as Villa matches the results of Watford and Bournemouth – who will face Arsenal and Everton respectively – they will avoid relegation to the Championship.
“We are in control of our own destiny and that’s what we wanted to have for the last game,” added Smith.
“It seemed unlikely and that we had to trust others, but the results have evolved over the week and we are above the dotted line at the moment.
“The most important thing is to be over that dotted line on Sunday and we know we have to win to ensure that. We will do everything to win. “