Azaria said earlier this year that he would no longer play the character, which has been criticized as a negative portrayal of South Americans of Asian descent.
Azaria also voiced characters from the black police officer Lou and the Mexican-American Bumblebee Man. Harry Shearer played Dr. Hibbert, who is black.
Friday’s statement did not say whether Apu or the other characters would stay on the series.
Bumbling Homer Simpson, housewife Marge, troublemaker Bart, prodigy Lisa and baby Maggie have captured America’s changing face for over 30 years in America’s longest-running scripted television show.
The simpsons is unionized in over 100 countries.
Friday’s announcement came amid widespread American pop culture accounts of racism following mass protests this month against police murders of black Americans.
Other white actors, including Mike Henry from the animated series Family guy and Kristen Bell from Central park, Also said that they will no longer hear colored characters.
“It was an honor to play in Cleveland on Family guy for 20 years. I love this character, but people of color should play characters of color. Therefore, I will be leaving this post, “said Henry on Twitter on Friday.