The coronavirus can trigger a “cytokine storm”. These drugs can calm him down.


The device, called CytoSorb, is about the size of a drinking glass and is filled with coarse polymers, each roughly the size of a grain of salt. Each grain or pearl has millions of pores and channels that total about seven football fields and filter out molecules about the size of cytokines. A cartridge can purify the entire body’s blood volume about 70 times in 24 hours.

Larger objects, like cells, surround the beads and are not affected, and smaller things like electrolytes pass directly, said Dr. Phillip Chan, managing director of CytoSorbents Corporation, which manufactures the device. CytoSorb can also eliminate certain proteins that the body needs.

But “in a potentially deadly disease when you have a cytokine storm,” said Dr. Chan, “it’s more or less a race to eliminate what will kill you against the temporary inconvenience of removing things from your body.” manufactures all the time anyway. “

  • Updated June 5, 2020

    • Does Covid-19 asymptomatic transmission occur?

      So far, the evidence seems to show it. A widely cited article published in April suggests that people are most infectious about two days before symptoms of coronavirus appear, and estimates that 44% of new infections result from the transmission of people who did not yet have symptoms. Recently, a senior expert from the World Health Organization said that transmission of the coronavirus by people who did not have symptoms was “very rare”, but then echoed the statement.

    • How does the blood group influence the coronavirus?

      A study by European scientists is the first to document a strong statistical link between genetic variation and Covid-19, the disease caused by the coronavirus. According to the new study, having type A blood was linked to a 50% increase in the likelihood that a patient would need oxygen or go on a ventilator.

    • How many people have lost their jobs due to coronavirus in the United States?

      The unemployment rate fell to 13.3% in May, the Department of Labor announced on June 5, an unexpected improvement in the country’s labor market, as hires rebounded faster than economists had expected. Economists had predicted that the unemployment rate would rise to 20%, after reaching 14.7% in April, the highest since the government began keeping official statistics after the Second World War. But the unemployment rate has plummeted, as employers added 2.5 million jobs after losing more than 20 million jobs in April.

    • Will the protests trigger a second wave of coronavirus?

      Mass protests against police brutality that have brought thousands of people onto American city streets raise the specter of new coronavirus outbreaks, prompting political leaders, doctors and public health experts to warn that crowds could cause an outbreak of cases. While many political leaders have asserted the right of protesters to speak out, they have urged protesters to wear face masks and maintain social distancing, both to protect themselves and to prevent the spread of the virus in the community . Some infectious disease experts have been reassured that the protests were held outdoors, saying that outdoor settings could reduce the risk of transmission.

    • How do we start exercising again without hurting ourselves after months of lockout?

      Exercise researchers and doctors have a few simple tips for those of us who want to start exercising regularly now: start slowly, then speed up your workouts, also slowly. American adults tended to be about 12% less active after the start of house arrest warrants than in March. But there are steps you can take to make it easier to get back to regular exercise safely. First, “start at no more than 50% of the exercise you did before Covid,” says Dr. Monica Rho, chief of musculoskeletal medicine at the Shirley Ryan AbilityLab in Chicago. Also put on preparatory squats, she advises. “When you haven’t exercised, you lose muscle mass. Expect muscle aches after these preliminary sessions after the lockout, especially a day or two later. But sudden or increasing pain during exercise is a call to the bugle to stop and go home.

    • My condition reopens. Is it safe to go out?

      States are gradually reopening. This means that more public space is available and that more and more businesses are allowed to reopen. The federal government largely leaves the decision to the states, and some heads of state leave the decision to local authorities. Even if you are not told to stay at home, it is still a good idea to limit outdoor travel and your interaction with others.

    • What is the risk of catching a coronavirus from a surface?

      Touching contaminated objects and then getting infected with germs is usually not the way the virus spreads. But it can happen. A number of studies on influenza, rhinovirus, coronavirus and other microbes have shown that respiratory illnesses, including the new coronavirus, can be spread by touching contaminated surfaces, especially in places like daycares , offices and hospitals. But a long chain of events has to happen for the disease to spread this way. The best way to protect yourself from coronavirus – whether surface transmission or close human contact – is social distance, washing your hands, not touching your face, and wearing masks.

    • What are the symptoms of coronavirus?

      Common symptoms include fever, dry cough, tiredness and difficulty breathing or shortness of breath. Some of these symptoms overlap with those of the flu, making detection difficult, but runny noses and blocked sinuses are less common. The C.D.C. also added chills, muscle aches, sore throat, headache and further loss of taste or smell as symptoms to watch for. Most people get sick five to seven days after exposure, but symptoms can appear in as little as two days or up to 14 days.

    • How can I protect myself while flying?

      If air travel is unavoidable, there are steps you can take to protect yourself. Most importantly, wash your hands often and stop touching your face. If possible, choose a window seat. Emory University study found that during flu season, the safest place to sit on a plane is near a window because people sitting on window seats have less contact with potentially sick people. Disinfect hard surfaces. When you get to your seat and your hands are clean, use disinfectant wipes to clean the hard surfaces of your seat such as the headrest and armrests, the seat belt buckle, the remote control, the screen, the back seat pocket and tray table. If the seat is hard and non-porous or made of leather or leather, you can also wipe it down. (Using wipes on padded seats could lead to a wet seat and the spread of germs rather than killing them.)

    • Do I have to wear a mask?

      The C.D.C. recommended that all Americans wear cloth masks if they go out in public. This is a change in federal guidelines reflecting new concerns that the coronavirus is spread by infected people who have no symptoms. So far, the C.D.C., like the W.H.O., has advised ordinary people not to wear masks unless they are sick and coughing. Part of the reason was to preserve medical grade masks for healthcare workers who desperately need them at a time when they are in constant shortage. Masks are no substitute for hand washing and social distancing.

    • What should I do if I feel sick?

      If you have been exposed to, or think you may have, a coronavirus and have a fever or symptoms such as coughing or difficulty breathing, call a doctor. They should give you advice on whether you should get tested, how to do it, and how to get medical treatment without potentially infecting or exposing other people.

In Europe, where CytoSorb has been marketed since 2013, it has been used more liberally. In the United States, the device was only authorized for patients who had exhausted all other options. Even now, during the pandemic, its use is only allowed in critically ill coronavirus patients with imminent or confirmed respiratory failure.

Dr. Stephan Ziegeler, who heads a specialized pulmonary intensive care unit at a hospital in Ibbenbüren, Germany, has so far treated eight people with CytoSorb. (Since 2018, he has received speaking fees from the manufacturer of CytoSorb, totaling 5,000 euros, or approximately $ 5,600). Of these, three have been released, three are in the process of being weaned from ventilation and two have died.

Bacterial septicemia patients typically need a maximum of three cartridges – one a day at $ 1,200 – but coronavirus patients have such astronomical levels of cytokines, said Dr. Ziegeler, that some have needed dozens of cycles, with two fresh cartridges per day.

“It looks like Covid-19 has a prolonged cytokine storm – a prolonged and truly effective inflammatory state compared to other sepsis states,” he said.


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