The Gunners return to action for the first time since the end of Alexandre Lacazette goal found the back of the net during a 1-0 victory over West Ham United at The Emirates on March 7.
Since then, the global health crisis took over – allowing injured players to recover. Calum Chambers remains in the gap while Lucas Torreira is a major doubt and unlikely to be risked as he is recovering from a broken ankle.
Cédric Soares also remains sidelined after picking up a facial injury and missed two closed-door friendlies against Championship sides Charlton Athletic and Brentford. Hector Bellerin and Kieran Tierney are back.
Pablo Husband has started 1-0 victory against West Ham and the January recruit could be in line to make his third competitive appearance for The Gunners since he joined the club on loan from Brazilian side Flamengo.
Eddie Nketiah is unlikely to be thrown in the deep end against Manchester City and with Tierney back, Bukayo Saka could go to the front of the left wing and allow Pierre-Emerick Aubameyang for the start-up of the front.
We expect two changes from the win over West Ham, with Bellerin and Tierney back on the side instead of Nketiah and £18million signing (Star), Sokratis, who has played right-back against West Ham.
Bernd Leno; Hector Bellerin, Pablo Husband, David Luiz, Kieran Tierney; Granit Xhaka, Dani Ceballos; Nicholas Pepe, Mesut Ozil, Bukayo Saka, Pierre-Emerick Aubameyang.