Cristiano Ronaldo scored his 23rd goal of the season as Juventus scored seven points ahead of Serie A with a win over Lecce, 10 players.
Fabio Lucioni had the visitors sent off in the first half before Paulo Dybala hit from outside the box just after the break.
Ronaldo brought home a powerful penalty after being shot before putting up replacement Gonzalo Higuain.
Defenseman Matthijs de Ligt then headed towards the end of the third for the dominant hosts.
Ronaldo, who also scored a penalty in the 2-0 win at Bologna on Monday, has now scored 23 goals in 24 league games this season.
The victory means Juventus are extending their advantage over Lazio, the title rival, who has a game in hand and could reduce the deficit to four points by beating Fiorentina on Saturday.