COVID-19 in 7780 pediatric patients: a systematic review

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1Aghdam, MCase reportIran10.0421100%)Fever, lethargy, mottling, respiratory distressCBC, BUN, Cr and ABG normalNormal CXR, no lung scannerLiquids, oxygen, antibiotics, oseltamivir12Almeida, FCase reportBrazil1ten0
(0%)Fever, cough, sore throat, gross hematuriaUrinalysis showed normal red blood cellsNRNR03Alonso Diaz, CCase reportSpain10.0220
(0%)Tachypnea, retractions and desaturations 9 days after birthNormal CRP and capillary gasCXR: opacities of frosted glass in the right perihilar regionObservation14Year, PCase reportChina130
(0%)AsymptomaticNRCT: bilateral consolidation and opacities in frosted glassAntibiotic05Andina, DCase series *Spain1NR0
(0%)Mild gastrointestinal symptoms and frostbite on the feetNRNROral analgesic, antihistamine, topical corticosteroids for some patientsNR6Andre, NCase seriesFrance59.62
(40%)Respiratory compromise in children with oncological diseaseNRNRNR57Bi, QCase seriesChina32NRNRBest recovery time in children under 9 years old (17.5 days) vs 10-19 years old (19.1 days), secondary household attack rate ~ 7.25%NRNRNRNR8Cai, JCase seriesChinaten6.174
(40%)7 patients with fever, 6 with cough, 4 with sore throat, 0 with diarrhea, all patients were symptomatic↑ CRP (n = 8), ↑ PCT (n = 6), ↑ LDH (n = 3); ↑ WBC (n = 3), ↑ D-dimer (n = 2)CXR: sparse unilateral infiltrates (n = 4)Symptomatic treatment (n = 5), symptomatic treatment + antibiotics (n = 5)09Cai, JHCase reportChina171
(100%)Fever, cough, rhinorrhea, nausea↑ WBC, CRP and D-dimerCXR: bilateral thickening of the lung textureObservation, Chinese medicines0tenCalvo, Ccross sectionSpain52.50
(0%)NRNRNRNRNR11Canarutto, DCase reportItaly10.0881
(100%)Fever, cough and rhinorrheaMild neutropenia, monocytosis and reactive lymphocytes on a blood smearCXR: normalNRNR12Carrabba, GCase reportItaly10.671
(100%)Mild temperature, dry coughNRCXR: no apparent interstitial pneumonia but slight clouding of the left lung, no pulmonary scannerNeurosurgery for x2 shunt revision013CDC COVID 19 intervention teamCase seriesUnited States25729.81408 (57%)Symptom data available for 291 patients: 56% of pediatric patients reported fever, 54% reported cough and 13% reported shortness of breath, 53 of 78 cases reported no symptoms, 23% (n = 80) of 345 patients had at least 1 underlying medical condition, 3 deathsNRNRNR1514That, ECase seriesSpain1510.114
(93%)Fever (n = 10), cough (n = 6), asymptomatic (n = 2), hypoxemia (n = 2), all patients with oncological diseaseWBC 3.2 median, 18.2% lymphocyte median, normal D-dimer medianCXR: normal (n = 6), pneumonia (n = 4), peri-bronchial handcuffs (n = 4)Hydroxychloroquine (n = 11), tocilizumab & lopinavir / ritonavir (n = 1), oxygen (n = 2), antibiotic (n = 2), remdesivir (n = 1), no treatment (n = 4)NR15Chacon-Aguilar, RCase reportSpain10.071
(100%)Paroxysmal episodes with generalized hypertonia, fever, rhinorrhea, vomiting, diarrheaCBC, normal liver and kidney studies, ↑ CK (380 U / L), ↑ LDH (390 U / L), normal CRPNRAntibiotics016Chan, JFCase series *China1ten1
(100%)AsymptomaticNormal CBC, fibrinogen, CRP, Cr, LDH and CK, ↑ alkaline phosphataseCT: bilateral opacities in frosted glassNR017Chang, DCase seriesChina28.5NRFever, coughNRNRNR018Chen, FCase reportChina11.081
(100%)Fever, shortness of breath, vomiting, diarrhea, myalgia / fatigue, cold limbs with poor perfusionNormal ABG, coagulation profile; LFT, ↑ BUN, Cr, CK, serum amyloid, IL-6, IL-10CXR: large blurred image of the upper right and lower lung; @ CT: improved texture of the two lungs, large consolidation on the right, shade in frosted glassContinuous dopamine, IV bolus, respiratory support, acidosis correction, interferon, glucocorticoid, oseltamivir, antibiotics, abdominal decompression119Chen, HCase reportChina1121
(100%)Fever, cough, abdominal pain, sputum production, no vomitingNormal CBC, ↑ CRP@ CT: pneumonia in the right superior lung, followed by bilateral opacities in frosted glassAntibiotics, arbidol and supplemental oxygenNR20Chen, JCase seriesChina1214.56
(50%)Cough (75%), fever (58.3%), diarrhea (33%), dizziness (16.7%), sore throat (16.7%)Normal CBC, LFT, BUN, PT, ↑ total B and T cells compared to adults, but comparable NK, IgM, IgG and C3 cellsThe opacity of frosted glass was the most common finding on chest CTAll patients received interferon, 8 received lopinavir / ritonavir and 2 received ribavirin021Cui, YCase reportChina10.150
(0%)Pharyngeal hyperemia, rhinorrhea, cough, sputumSlightly elevated IgM, lymphocyte and platelet counts; Hgb normal, D-dimer, PTT, PT, CRP, ESR and renal function@ CT: unilateral opacity of the frosted glass in the right lung and unilateral consolidationInterferon, antibiotic, ursodeoxycholic acid, Chinese medicine122from Rojas, TCase seriesSpain1510.114
(93%)10 patients had fever, 6 patients had cough, 1 with hypoxemia and 2 asymptomatic patients; all patients had underlying oncological diseaseThe median number of white blood cells was 3,195 and the median number of lymphocytes was 580CXR: normal (n = 6), pneumonia (n = 4), peri-bronchial handcuffs (n = 4)11 patients received hydroxychloroquine and 2 antibiotics, tocilizumab (n = 1), lopinavir-ritonavir (n = 1), glucocorticoids (n = 1) and remdesivir (n = 1)023Denina, MCase seriesItaly84.25
(63%)Fever (n = 6), dry cough (n = 5), dyspnea (n = 3), pharyngeal congestion (n = 3), vomiting or diarrhea (n = 3), hypoxemia (n = 2)NRCXR: pulmonary consolidation (n = 1), opacities in frosted glass (n = 4); LUS: confluent B lines (n = 5), sub-pleural consolidations (n ​​= 2)Oxygen (n = 2)NR24Dona, DCase seriesItaly20.29NRFever (n = 1) diarrhea (n = 1), respiratory symptoms in bothNRNRNR025Dong, LCase reportChina10.0030
(0%)AsymptomaticThe nasopharyngeal test was negative, but IgM and IgG were elevated 2 hours after birth, ↑ IL-6, IL-10, LDHCT: normalNR126Dong, YCase seriesChina731ten420
(58%)315 mild illnesses, 300 moderate illnesses, 18 serious and 3 seriously ill, 94 asymptomatic childrenNRNRNRNR27Du, WCase seriesChina147.16
(43%)Fever (n = 5) and cough (n = 3) were frequently reported; Eight (57.1%) were asymptomatic↑ LDH (n = 7), ↑ PCT (n = 5), ↑ D-dimer (n = 5), ↑ CK (n = 4), leukopenia (n = 4), ↑ IL-6 (n = 1)CT: bilateral (n = 6) and unilateral (n = 5) lung injuryNR028Fan, QCase reportChina10.250
(0%)Fever and diarrheaNeutrophilia (86.2%), lymphopenia (7.1%)CT: normalSupportive care029Feng, KCase seriesChina1574
(33%)Asymptomatic (n = 8), fever (n = 5), cough or nasal congestion (n = 1)↓ WBC (n = 8), WBC normal (n = 7)@ CT: frosted glass lesions (n ​​= 7), no lesion (n = 6), uneven shadow (n = 2)NRNR30Ferrazzi, ECase seriesItaly30.003NR1 newborn baby with gastrointestinal and respiratory symptoms 3 days after birthNRNRNR131Genovese, GCase reportItaly180
(0%)Fever, cough, papular rash on the trunkNormal full blood count, CRP, liver and kidney function, mild thrombocytopenia (105k)NRNRNR32Guan, WCase seriesChina9NRNRNRNRNRNRNR33Gubjartsson, Dcross sectionIceland1321NRNRNRNRNRNRNR34Han, MCase reportKorea10.070
(0%)Fever, cough and vomiting; viral excretion in the urine and stool for 10 and 18 days, respectivelyFirst CBC with mild neutropenia (817 per mm3)CXR: normalNo antibiotics or antivirals035Han, YCase seriesChina744
(57%)Fever (n = 5), cough (n = 5), shortness of breath (n = 3), vomiting (n = 4), diarrhea (n = 4), sore throat (n = 1), myalgia (n = 1)↑ BNP (n = 5), ↑ CK (n = 4), ↑ PCT (n = 3), ↑ AST (n = 3), ↑ LDH (n = 2), ↑ CRP (n = 2)Pneumonia on CT and CXR (n = 5)Oxygen therapy (n = 2) glucocorticoids (n = 1)036Hrusak, Ocross sectionCzech Republic, United States, Italy, Spain, Switzerland, Denmark, Austria, Sweden, Belgium, Netherlands9NRNRFever (n = 7) and diarrhea (n = 1) were the most common symptoms in this cohort of children with oncological diseaseLymphopenia (n = 1), neutropenia (n = 5)Normal CXR in 1 patient, all other NRsAntibiotics (n = 2) lopinavir / ritonavir (n = 1) hydroxychloroquine (n = 2)037Hu, XCase series *China10.0041
(100%)AsymptomaticWBC, Hgb, Plts, CRP, Cr, normal ALT, ↑ PCT (n = 6)Normal CXR = 1; no CT dataNR038Ibrahim, LCase seriesAustralia413.11
(25%)Sore throat (n = 4), headache / dizziness (n = 3), cough (n = 2), fever (n = 1)NRNRNo039Ji, LCase seriesChina2122
(100%)Fever and diarrhea (n = 1)↑ WBC (n = 1), ↑ CRP (n = 1)CT: normal (n = 2)Symptomatic treatment, oral probiotic040Ji, TCase seriesChina19NRNRAsymptomatic (n = 9)NRNRNRNR41Jiang, SCase seriesChina25.080
(0%)Fever, cough and vomiting in both patients↑ WBC, neutrophil count, CRP, PCT, amyloid serum A (n = 1)@ CT: normal (n = 1), bilateral opacities in frosted glass with uneven shadows (n = 1)Antibiotics (n = 2), oseltamivir (n = 1), glucocorticoids (n = 1), IVIG (n = 1)142Jones, VCase reportUnited States10.50
(0%)Difficult, conjunctivitis, dry, chapped lips, prominent tongue papilla, polymorphous maculopapular rash, swelling of the hands and feet, fever, anorexiaWBC with bandemia, ↑ CRP, normal ESR, BMP and LFTCXR: low opacity in the left lungIVIG and acetylsalicylic acidNR43Kam, KCase reportSingapore10.51
(100%)Asymptomatic at the start, followed by feverViremia, normal CBC, LFTNRNRNR44Kan, MCase reportUnited States10.020
(0%)Fever, tachycardia, cough; underlying state of hydronephrosis and duplication of the renal systemLeukopenia, lymphopenia, neutropenia, normocytic anemia, normal platelets, normal CRPNRBolus, antibiotic, antipyretic045Korean Infectious Disease Societycross sectionKorea201NRNRNRNRNRNRNR46Lai, WCase seriesChina2142
(100%)2 with dry cough, 2 with fever and 1 with malaiseNR@ CT: unilateral and uneven ground glass opacities (n = 2)Antivirals, solidarity047The, HCase reportVietnam10.250
(0%)Rhinorrhea and nasal congestion, pickyNormal CBC, CK, LDH, CRP and PCTCXR: normalAntibioticNR48Leva, ECase seriesItaly16NRNRAll patients with fever and coughNRNRNR449Li, HCase seriesChina405.123
(58%)Cough (n = 27), fever (n = 21), myalgia (n = 4), diarrhea (n = 4), rhinorrhea (n = 2), sore throat (n = 2)Normal CBC, CRP, PCT, ↑ CD3+, CD8+ lymphocyte (n = 40), ↑% of CD3+ (n = 40), and ↓ percentage of CD19+ lymphocyte (n = 40)@ CT: opacities in frosted glass unilateral (n = 13), bilateral (n = 26), normal (n = 1)Interferon (n = 40), oseltamivir (n = 20), IVIG (n = 4), steroids (n = 3), azithromycin (n = 13), mechanical ventilation (n = 1)150Li, JCase reportChina10.670
(0%)CoughWBC and differential, PT, D-dimer, LFT and normal renal function, ↑ CRPNormal CTInterferon051Li, MCase reportChina10.0061
(100%)Patient has no fever or coughNRNRNR052Li, WCase seriesChina47.24
(100%)CoughNRNRNRNR53Li, WeiCase seriesChina53.44
(80%)Asymptomatic (n = 4), 1 patient with rhinorrhea, cough, sore throat and fever↑ WBC (n = 2), ↑ CRP (n = 1)CT: irregular frosted glass opacities (n = 3), normal (n = 2)IVIG (n = 5), antivirals (n = 2), montelukast (n = 3), interferon (n = 2)NR54Li, YCase seriesChina241
(50%)Cough and rhinorrhea (n = 1)↓ neutrophils (n = 1), ↑ CRP (n = 1), normal coagulation profile, LFT and renal function in both patients@ CT: bilateral spots upper lobes (n = 1), increase in the bronchovascular bundles bilaterally (n = 1)Oxygen (n = 1)055Lin, JCase reportChina170
(0%)Nasal congestion and dry cough; no fever, dyspnea or diarrheaNRCT showed no signs of pneumoniaSupportive therapy, oseltamivir and interferonNR56Liu, MCase seriesChina56.44
(80%)3 were asymptomatic, 2 patients with fever and dry coughWBC normal, mild neutropenia (n = 3)@ CT: opacities in frosted glass unilateral (n = 3) and bilateral (n = 1)Interferon (n = 4), ribavirin (n = 3)NR57Liu, WCase seriesChina63.52
(33%)High fever and cough in all patients; vomiting (n = 4)White blood cells (n = 4), lymphocytes (n = 6) and neutrophils (n = 3) have decreased@ CT: unequal bilateral shades (n = 3), irregular opacities in frosted glass in the two lungs (n = 1), normal (n = 1)Oseltamivir (n = 6), glucocorticoid (n = 4), ribavirin (n = 2), IVIg (n = 1)158Liu, YCase reportChina1ten1
(100%)AsymptomaticCBC normal, LFT, ↑ LDH, limit ↑ CRP@ CT: opacity of the frosted glass and pleural effusionRibavirin, interferon059Locatelli, ACase reportItaly1161
(100%)Mild diarrhea and pseudo-frostbite lesions on fingers and toeCoagulation, autoimmunity, normal cryoglobulinsNRNRNR60Lou, XCase seriesChina34.81
(33%)All the patients had fever; 2 with fatigue, nasal congestion, diarrhea and headacheNRNRInterferon (n = 2)061Read, XCase seriesChina1716.4104
(61%)Fever (41.5%), pharyngeal erythema (46.2%), diarrhea (8.8%), asymptomatic (15.8%), 1 death↓ WBC (26.3%), lymphopenia (3.5%), ↑ PCT (64%), ↑ CRP (19.7%), ↑ D-dimer (14.1%), ↑ AST (14.6 %)@ CT: opacity of the frosted glass (32,7%), irregular shading unilateral or bilateral (31%), interstitial anomalies (1,2%)NR362Lu, YCase seriesChina97.85
(56%)Fever (n = 6), cough (n = 3), asymptomatic (n = 1)All WBC accounts were normalCXR: no obvious anomaly (n = 5); @ CT: no obvious anomaly (n = 4), opacities in frosted glass (n = 4)NR063Lu, YingyingCase seriesChina1105.859
(53%)Cough and dyspnea (51.8%), followed by fever (50.9%) were the most common symptoms, 26 (23.6%) patients had gastrointestinal symptoms, 29 (26.4% ) were asymptomaticSymptomatic patients were more likely to have ↓ Hgb (16.4% vs 0%), ↑ AST (23.5% vs 0%) and tended to have ↑ IL-6 (12% vs 0%)64 patients had a chest x-ray showing pneumoniaAll received antivirals, interferon was the most widely used Chinese drug (n = 22)064Ma, HCase seriesChina503.328
(56%)32 with fever, 22 with cough, 8 with rhinorrhea, 1 with sore throat, 2 with myalgia, 3 with diarrhea, 6 without symptomsLeukocytosis (n = 2), leukopenia (n = 19), polycythemia (n = 2), thrombocytopenia (n = 7), ↑ CRP (n = 10)@ CT: opacities of the frosted glass (n = 29), irregular local shading (n = 9), normal (n = 7)NRNR65Ma, H2Case seriesChina225.512
(55%)Fever (n = 13), dry cough (n = 5), shortness of breath (n = 1), asymptomatic (n = 2)NR@ CT: frosted glass shadows (n = 6), consolidation (n = 4), frosted glass shadows and consolidation (n = 6), bronchial pneumonia type changes (n = 3), normal (n = 3)NRNR66CanCase seriesChina115NR73
(64%)Asymptomatic (n = 61), fever (n = 29), cough (n = 47), rhinorrhea (n = 47), gastrointestinal symptoms (n = 3)WBC normal (n = 88), ↓ WBC (n = 23); normal lymphocytes (n = 60), ↑ lymphocytes (n = 40); normal neutrophils (n = 77), ↑ neutrophils (n = 32), ↑ ALT (n = 11), ↑ CK-MB (n = 34), ↑ BUN / Cr (n = 2)CT: opacities of frosted glass (n = 49), normal (n = 27)NRNR67Mansour, ACase reportLebanon11.330
(0%)Patient with fever, diarrhea and decreased activityLeukocytosis, elevated platelets, elevated CRP, decreased hemoglobin / hematocritCXR: unilateral, large consolidation with bronchial infiltrateHydration and antibiotics068Mao, LCase reportChina11.161
(100%)Patient presented with fever, cough, congestion, rhinorrhea, decreased appetiteNormal CBC, PCT, LFT, renal function, D-dimer; normal T cell, B cell and NK cell, ↑ CRP@ CT: unilateral opacities of the frosted glass in the lower right lungInterferon and support069Mizumoto, KCase seriesJapan3NRNRAsymptomatic (n = 2)NRNRNRNR70Morey-Olive, MCase seriesSpain231
(50%)Low grade fever (n = 2)Abnormal liver enzymes and coagulation parameters in 1 patientNRNR071Munoz, ACase reportUnited States10.061
(100%)Nasal congestion, tachypnea, reduced diet, subsequent pneumothorax↑ PCT (6.53 ng / mL) and ↑ CRP (172 mg / L)CXR: bilateral linear opacities and consolidation of the right upper lobeMechanical ventilation, antibiotics, hydroxychloroquine, vasopressors172Nathan, NCase seriesFrance50.185
(100%)All had fever, 4 patients with hypotonia or drowsiness and moaning, 4 with cough and rhinorrheaNormal CBC, ↑ CRP (n = 3), ↑ PCT (n = 1)Normal CXR in 4 patients, 1 patient with hyperinflationAntipyretics073Ng, KCase seriesUnited Kingdom80.392
(25%)Fever (n = 5), anorexia (n = 4), tachypnea (n = 2), skin mottling (n = 1)2 patients had neutropenia and thrombocytosis2 patients had some opacities on CXR4 patients treated with broad spectrum antibiotics274Odievre, MCase reportFrance1160
(0%)Fever, followed by acute chest syndrome in a sickle cell patient↑ CRP, ↑ D-dimer, ↑ IL-6, ↑ LDH, ↑ TNF-α@ CT: bilateral pulmonary embolisms and bilateral consolidation with halo on the rightAcetaminophen, non-invasive ventilation, blood transfusion, anticoagulation, tocilizumab175Pan, ACase seriesChina536NRNRNRNRNRNRNR76Park, JCase reportKorea1ten0
(0%)Low intensity fever and sputum productionCBC, normal CRP, stool sample remained positive for 17 days after onset of symptoms@ CT: scattered or nodular unilateral consolidations with peripheral opacities in ground glassNo077Parri, NCase seriesItaly100657
(57%)Fever (n = 54), cough (n = 44), rhinorrhea (n = 22), asymptomatic (n = 21), shortness of breath (n = 11), nausea (n = 10), vomiting (n = 10), diarrhea (n = 9), myalgia (n = 9), sore throat (n = 4), headache (n = 4); 27 patients with underlying medical conditionsWBC normal (n = 40), ↓ WBC (n = 11), lymphocytopenia (n = 14), ↑ PCT (n = 4), ↑ LDH (n = 22), ↑ ALT (n = 8), ↑ AST ( n = 10)CXR: interstitial anomaly (n = 14), normal (n = 15), consolidation (n = 6), pleural effusion (n = 1); LUS: interstitial syndrome (n = 9), small sub-pleural consolidations (n ​​= 4)Non-invasive ventilation; mechanical ventilation (n = 1)978Patek, PCase reportUnited States10.041
(100%)Fever, hypoxemiaNormal CBC, slight elevation at AST and ALT, CSF without particularityCXR: bilateral perihilar streaks without focal consolidationOxygen, empirical antibiotics, acyclovir179Patel, PCase reportUnited States1120
(0%)Fever, cough, vomiting, hematuria and respiratory failureSevere thrombocytopenia (CXR: bilateral opacities of diffuse airspace and small pleural effusionIVIg, corticosteroids, mechanical ventilation, nitric oxide, azithromycin, hydroxychloroquine, tocilizumab180Piersigilli, FCase reportBelgium10.0020
(0%)No COVID symptoms; the child is an extremely premature newborn↓ WBC and lymphopeniaNormal radiographic resultsContinuous positive airway pressure181Qian, GCase series *China11.080
(0%)AsymptomaticNRCT: normalNR082Qiu, HCase seriesChina368.323
(64%)Fever (n = 13), cough (n = 7), headache (n = 3), vomiting / diarrhea (n = 2)Leukopenia (n = 7), ↓ lymphocytes (n = 11), ↑ PCT (n = 6), ↑ CK-MB (n = 11)CXR: frosted glass opacities (n = 19)Interferon (n = 36), lopinavir / ritonavir (n = 14), oxygen (n = 6)NR83Qiu, LCase reportChina10.661
(100%)Fever, cough, wheezing, apnea, mottled skin, petechiae, cold fingers; patient with a history of heartThe first laboratories demonstrated lymphopenia, ↓ CD3 +, ↓ CD4 +, ↓ CD8 +, ↓ fibrinogen, ↑ LDH, normal PCT and renal functionCXR: increased density, profusion, thickened lung texture; CT: multiple opacities in frosted glass and uneven, high density shadowsIVIg, lopinavir / ritonavir, methylprednisolone, fluids, electrolytes, pressers184Robbins, ECase reportUnited States10.161
(100%)FeverCBC within normal limits, CMP normal except for slightly elevated alkaline phosphatase and calciumCXR: normalAntibiotics, supportNR85Schwierzeck, VCase seriesGermany3tenNRAsymptomatic (n = 2), fever (n = 1), cough (n = 1), nasal congestion (n = 1) in patients with renal impairmentNRNRNRNR86See, KCase seriesMalaysia46.43
(75%)Mild fever and diarrhea (n = 1); rhinorrhea (n = 1), cough and fever (n = 1 mild), asymptomatic (n = 1)NRCXR: perihilar opacities (n = 2)Antipyretics (n = 2), antibiotic (n = 1), rehydration (n = 1), salbutamol (n = 1)087Shekerdemian, Lcross sectionUSA, Canada4811.325
(52%)11 patients (23%) with multi-organ failure, 73% (n = 35) with pulmonary symptoms, 40% (n = 19) of children were medically complexNRNRNo medication (n = 20), hydroxychloroquine (n = 21), 17% received antiviral therapy, tocilizumab (n = 5), mechanical ventilation (n = 18), azithromycin (n = 8)88Shen, QCase seriesChina97.53
(33%)2 asymptomatic, 3 with fever, 1 with diarrhea, sore throat or cough and 1 with fever and diarrhea↑ WBC (n = 1), ↑ lymphocyte count (n = 1), ↑ CRP (n = 1), ↑ ESR (n = 4), ↑ LDH (n = 4)Normal chest X-ray and lung CT scan in 7 patients, 2 (22.2%) with small frosted glass opacitiesAll received oxygen and lopinavir / ritonavir, antibiotic treatment for 5 children, glucocorticoids and IVIg for 1 patient089Shi, BCase reportChina10.231
(100%)Cough, wheezing, dyspneaWBC normal, ↑ lymphocyte and platelet count; Normal IgG, IgM, IgA, T, B and NK cells, normal LFT, RSV +CT: consolidation of the left lower lobeAntibiotics, CPAP, IVIg, corticosteroids, interferon, Chinese medicines190Shi, Ycross sectionChinaten65
(50%)NRNRNRNR091Sieni, ECase reportItaly11.080
(0%)Fever, vomiting and diarrhea; patient atteint d’une maladie oncologique sous-jacenteLeucopénie, anémie, thrombocytopénieCXR: résultats réticulaires bilatérauxAntifongique, antibiotiques, hydroxychloroquine, lopinavir / ritonavir092Sinelli, MTRapport de casItaly10,0061
(100%)Hypoxémie, cyanose périorale, mauvaise succionNumération sanguine complète normale et protéine C-réactiveTDM: opacités bilatérales douces du verre dépoliSupport d’oxygène193Song, RSérie de casChina73.51
(14%)La plupart asymptomatiques, seulement 2 avaient de la fièvreWBC normal, ↓ neutrophiles, ↑ LDH, fibrinogène normalNRTous les patients ont reçu des soins de soutien, interféron, lopinavir / ritonavirNR94Song, WSérie de casChina167,9ten
(63%)Asymptomatique (n = 8), toux (n = 6), fièvre (n = 5)Leucocytes normaux (n = 14), CRP normaux (n = 15), foie, rénal, coagulation, électrolytes et laboratoires myocardiques étaient normaux, ↑ LDH (n = 3)TDM: normal (n = 5), opacités bilatérales en verre dépoli (n = 8), consolidation bilatérale (n = 1), ombre inégale / nodulaire (n = 3)Oseltamivir (n = 11), antibiotiques (n = 9), lopinavir / ritonavir (n = 4), médecine chinoise (n = 13), arbidol (n = 6)095Su, LSérie de casChina93.53
(33%)Asymptomatique (n = 6), fièvre ou toux (n = 3)↑ CK-MB (n = 6), ↓ WBC (n = 2), LFT normaux, les marqueurs inflammatoires (CRP, PCT, ESR, IL-6) étaient normaux chez tous les patients, selles positives chez 5 enfants justifiant une réadmissionTDM / radiographie: normale (n = 5), bronchite (n = 2), consolidation pulmonaire et opacités en verre dépoli (n = 1), bronchopneumonie (n = 1)Interféron administré à tous les patients; ribavirine (n = 1)096Soleil, DSérie de casChina86,66
(75%)Tachypnée (n = 8), fièvre ou toux (n = 6 chacun), production d’expectorations (n ​​= 4), nausées / vomissements (n = 4), diarrhée (n = 3), fatigue ou maux de tête (n = 1 chacun)Normal / ↑ WBC (n = 7), ↑ CRP, ↑ PCT, ↑ LDH (n = 6), LFT anormaux (n = 4)TDM / radiographie: plusieurs ombres en forme de patch (n = 6), opacités en verre dépoli (n = 6), pneumonie unilatérale (n = 2), pneumonie bilatérale (n = 6)Oxygène (n = 6), ventilation mécanique (n = 2), tous les patients ont reçu des antiviraux (virazole, oseltamivir, interféron), des antibiotiques (n = 5), des glucocorticoïdes (n = 5), des IgIV (n = 4), des médicaments chinois (n = 4)397Soleil, KSérie de casChina13NRNRNRNRNRNRNR98Soleil, MSérie de cas*China10,021
(100%)NRNRNRNR099Tagarro, ACoupe transversaleSpain413.318
(44%)Symptômes respiratoires supérieurs dans 14 (34%), fièvre (n = 11), gastro-entérite ou vomissements (n = 2)NRNR25 (60%) ont dû être hospitalisés, 2 ont reçu une ventilation non invasive et 1 a été intubé4100Tan, XSérie de casChina137,94
(31%)Symptômes respiratoires (n = 7), toux (n = 6), faible fièvre (n = 6), mal de gorge (n = 2), asymptomatique (n = 2)LFT, enzymes myocardiques, PCT, coagulation, ferritine étaient normaux, ↑ ESR (n = 3), augmentation du taux de CRP (13,2 mg / L)CT: normal (n = 7); anormal: ombres en forme de cordon (n = 2), montrait des ombres en verre dépoli (n = 2), avait une ombre inégale à haute densité (n = 2)Lopinavir / ritonavir (n = 12), interféron (n = 10), arbidol (n = 6)0101Tan, YSérie de casChinaten73
(30%)4 patients avec de la fièvre, 3 avec des symptômes respiratoires et 1 avec des vomissementsCBC normal (n = 9), ↑ WBC et lymphocytes (n = 1), ↑ AST (n = 2), CRP, LDH et ferritine normaux chez tous les patients, mycoplasme + (n = 3)CT: opacités en verre dépoli (n = 5)Tous les patients traités avec un soutien symptomatique0102Tang, ARapport de casChina1ten1
(100%)AsymptomatiqueCBC: normalCT: normalArbidol, interféron, médicament chinois0103Tong, ZSérie de cas*China1121
(100%)NRNRNRNRNR104Turner, DSérie de casIsraël, Chine, Espagne, Italie, Corée, États-Unis, Royaume-Uni, Portugal, France8165
(63%)Fièvre (n = 3), toux (n = 3), myalgie / fatigue (n = 4) chez les enfants atteints d’une maladie inflammatoire de l’intestinNRNR5ASA (n = 4), infliximab (n = 2), thiopurines (n = 4), glucocorticoïdes (n = 1)0105Wang, DSérie de casChina317.115
(48%)Asymptomatique (n = 4), fièvre (n = 20), toux (n = 14), fatigue et diarrhée (n = 3 chacun), maux de gorge (n = 2), maux de tête / étourdissements (n = 3), rhinorrhée ( n = 2), vomissements (n = 2)↓ Leucocytes et lymphocytes (n = 2), ↑ CRP (10%), ↑ PCT (4%), ↑ ESR (19%), ↑ transaminases (22%), fonction rénale normaleModifications pulmonaires par tomodensitométrie chez 14 enfants, dont 9 présentaient des opacités inégales en verre dépoliInterféron (n = 10), Antibiotiques (n = 6),
oseltamivir (n = 1), 18 étaient une combinaison d’interféron, d’oseltamivir, de ribavirine, d’arbidol et / ou de lopinavir / ritonavir0106Wang, HRapport de casChina181
(100%)FièvreNRCT: opacité du verre dépoli du lobe inférieur gaucheTraitement antiviral et symptomatiqueNR107Wang, JRapport de casChina10,051
(100%)Fièvre, toux, vomissements, diarrhéeÀ l’admission: ↓ WBC, ↑ monocytes, ↓ PltsTDM: pneumonie bilatérale et opacités bilatérales en verre dépoliInterféronNR108Wang, SRapport de casChina10,0031
(100%)AsymptomatiqueLymphopénie, ↑ AST, ↑ CK, ↑ bilirubine directe et totaleCT: opacités en verre dépoli unilatéralesAntibiotique, vitamine K, bolus1109Wang, YSérie de casChina436,9221
(49%)Les symptômes les plus courants étaient la dyspnée (87,5%), la fièvre (62,5%) et la toux (62,5%)IL-6, IL-10, D-dimère, bilirubine totale et acide urique étaient élevés dans les cas gravesTous les cas graves présentaient des lésions au scanner thoracique; opacités du verre dépoli (n = 24), consolidation inégale (n = 9)Tous les cas graves ont reçu de l’oxygène supplémentaire; 5 placés en mode respiratoire non invasif et 3 intubésNR110Wei, MSérie de casChina91.12
(22%)Asymptomatique (n = 6), fièvre (n = 4), toux (n = 2), rhinorrhée (n = 1), production d’expectorations (n ​​= 1)NRNRNR0111Wu, PRapport de casChina12,831
(100%)Conjonctivite et dermatite des paupièresCBC normal, CRP, CK, mesures hépatiques, ↑ CK-MB, ↑ LDH, ↓ créatinineCT pulmonaire normal et radiographieNRNR112Wu, QSérie de casChina746.844
(60%)Asymptomatique (40,5%), toux (32,4%) et fièvre (27,0%)Leucopénie (n = 4), lymphopénie (n = 4), ↑ CRP (n = 13), ↑ PCT (n = 2), ↑ ESR (n = 5); co-infection (n = 26)TDM: opacités du verre dépoli (n = 9), changements atypiques de bronchopneumonie et pneumonie virale commune (n = 28); normal (n = 37)Tous les patients ont reçu de l’interféron, des médicaments chinois et des antiviraux; 27 patients ont reçu des antibiotiques1113Wu, ZCoupe transversaleChina965NRNRNRNRNRNRNR114Xia, WSérie de casChina20NR13
(63%)Toux (n = 13), fièvre (n = 12), diarrhée (n = 3), dyspnée (n = 2), maux de gorge (n = 1), fatigue (n = 1)13 patients avec des lymphocytes élevés; 2 patients avec WBC élevéTDM: consolidation (n = 10), opacités en verre dépoli (n = 12), ombre (n = 4), nodules (n = 3)NRNR115Xing, YSérie de casChina3NRNRFièvre chez tous les patients, symptômes gastro-intestinaux (n = 1)SARS-CoV-2 détectable dans les selles pendant 1 à 3 semaines après une conversion négative dans des prélèvements de gorgeNRNR0116Xing, YHSérie de casChina34.22
(67%)Fièvre (n = 3), 1 patient avait de la toux et de la diarrhéeL’ARN viral est resté détectable dans les selles pendant plus de 4 semaines, leucocytose (n = 3), ↑ Plts (n = 2), ↑ PCT (n = 1), ↑ CRP (n = 1), ↑ LDH (n = 1) , ↑ D-dimère (n = 1)TDM: opacités en verre dépoli unilatérales (n = 1), consolidation unilatérale (n = 1), normale (n = 1); CXR: ombres inégales (n = 1)De l’interféron, de la ribavirine et des médicaments chinois ont été administrés à tous les patients0117Xu, YSérie de casChinaten7,546
(60%)Fièvre (n = 7), toux (n = 5), mal de gorge (n = 4), diarrhée (n = 3), rhinorrhée (n = 2), asymptomatique (n = 1)WBC compte normal, neutropénie (n = 4), lymphocytopénie (n = 3), lymphocytose (n = 1), ↑ PCT (n = 5), ↑ ESR (n = 3), ↑ CRP (n = 3), ↑ LDH (n = 2), ↑ D-dimère (n = 1), ↑ ferritine (n = 1), CK normalNRInterféron (n = 10), antibiotiques (n = 1), IVIG (n = 1)NR118Yin, XRapport de casChina191
(100%)Fièvre; pas de toux, mal de gorge ou nauséeLymphopénie, ↑ α hydroxybutyrate déshydrogénase, ↑ CRP, ↑ amyloïde, PCT normal et CKCXR: normalAntipyrétiqueNR119Yu, NCase reportChina10.004NRDyspnea; no fever, cough, or diarrheaNRCXR: mild pneumoniaObservation1120Zeng, LCase reportChina10.051
(100%)Sneezing, vomiting, lethargy, poor feeding↑lymphocytes, ↓neutrophils and procalcitoninCT: bilateral enhanced texture and blurred shadowsNR1121Zeng, LingkongCase seriesChina30.0033
(100%)Fever (n=2), lethargy (n=2), shortness of breath and cyanosis (n=1), vomiting (n=1)Leukocytosis (n=2), ↑PCT (n=1), ↑CK-MB (n=1), thrombocytopenia (n=1)CT: pneumonia (n=3)Mechanical ventilation (n=1), antibiotics (n=1)3122Zhang, BCase seriesChina468.7529
(63%)Asymptomatic (n=22), cough (n=15), fever (n=10), rhinorrhea/nasal congestion (n=6), sore throat (n=4), myalgia/fatigue (n=3)No leukopenia or lymphopeniaCXR: ground glass opacity (n=13), mixed ground glass opacity and consolidation (n=4), local patchy shadowing (n=1), consolidation (n=1)Most treated with 1-3 antiviral drugs0123Zhang, B2Case seriesChina39.32
(67%)Asymptomatic (n=2), crying (n=1), fever, cough, and malaise (n=1)PCT normal (n=3), lymphocytosis (n=1), ↑CRP (n=2), ↑CK (n=1), ↑LDH (n=1)CT: normal (n=2); CXR: bilateral pneumonia (n=1)Two hospitalizations for all patients due to persistent SARS-CoV-2 positivity; oseltamivir (n=2), arbidol and lopinavir/ritonavir (n=2), oxygen (n=2), all received Chinese medication0124Zhang, MCase series*China1151
(100%)Low-grade fever and myalgiaNRNRNRNR125Zhang, TCase seriesChina37.73
(100%)Fever (n=2), rhinorrhea (n=2), cough (n=1)Normal electrolytes, liver, and kidney function, normal PCT, LDH, and IL-6; 1 patient with elevated CRP (64.7 mg/L); immunologic profile normal, stool nucleic acid was still positive 10 days after clinical recoveryCT: ground glass opacities (n=2)Interferon, Chinese medications, and vitamin C for all patients, 1 patient received antibiotics0126Zhang, YCase reportChina10.250
(0%)Fever and sputum productionDecreased neutrophil count; elevated CRP and platelet count, normal PCTNRAmbroxol and aerosolization0127Zhang, ZCase seriesChina40.023
(75%)Fever (n=2), shortness of breath (n=1), cough (n=1), vomiting (n=1), and 1 asymptomaticNRCT: increased lung markings (n=3)Supportive0128Zhao, WCase seriesChina26.5NRNRNRNRNRNR129Zheng, FCase seriesChina255.114
(56%)Fever (n=13), cough (n=11), diarrhea (n=3), dyspnea (n=2), vomiting (n=2), abdominal pain (n=2), nasal congestion (n=2)Median WBC, lymphocytes, CRP, CK within normal limits; lymphopenia (n=10), normal renal and coagulation profile (n=23)CT: bilateral patchy shadows/consolidations (n=11), unilateral patchy shadows/consolidations (n=5), normal (n=8)Antiviral therapy (n=12, included interferon, arbidol, oseltamivir, and/or lopinavir/ritonavir), 13 received antibiotics; 2 patients were intubated, and given corticosteroids and IVIG2130Zhou, YCase seriesChina91.584
(44%)Asymptomatic (n=5), fever (n=4), cough (n=2), rhinorrhea (n=1)normal WBC (n=7), lymphocytosis (n=6), ↑LDH (n=2 of 4 samples), ↑CRP (n=2 of 7 samples)CT: ground-glass opacities (n=7), nodular morphology (n=6)Interferon (n=9), lopinavir (n=6)0131Zhu, LCase seriesChinaten95
(50%)Fever (n=4), cough (n=3), headache (n=2), asymptomatic (n=4)WBC, CRP and PCT normal in all children; ↑ALT (n=2)CT: pneumonia (n=5)Lopinavir/ritonavir (n=4), interferon (n=4), oseltamivir (n=1), antibiotics (n=1), oxygen (n=1), glucocorticoids and IVIG (n=0)0

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