LONDON – A trial of the AstraZeneca experimental COVID-19 vaccine in pigs found that administration of two doses of the University of Oxford-developed shot produced a greater antibody response than a single dose, the scientists said Tuesday.Research published by Britain’s Pirbright Institute found that giving the first the first, followed by a dose a shot booster elicited a greater immune response than a single dose – which suggests a two-dose approach may be more effective in obtaining protection against the disease caused by the new coronavirus.
The ChAdOx1 nCoV-19 vaccine was originally developed by researchers at the University of Oxford, who are now working with AstraZeneca on development and production.
The vaccine is already in the mid-stage of human trials, and AstraZeneca has said it hopes to have data showing efficacy later this year. Pigs are useful for model research for this type of vaccine and other trials have been able to predict the vaccine outcome in humans, especially in influenza studies. (Reporting by Kate Kelland, editing by Jason Neely)