The Reds are now the dominant force in England after adding the UEFA Super Cup and FIFA Club World Cup to the European Cup they won last season while maintaining a record 25 points at the top of the Premier League.
Jurgen Klopp’s team need only two more wins in their nine games remaining to secure the club’s first title since 1990 and to rank in one of United’s 20 records.
United, without a championship for seven years, is in fifth place and holds 37 points in Liverpool.
But Old Trafford midfielder Fred believes meeting the world champions remains the biggest game of the season for Ole Gunnar Solskjaer’s team.
Speaking of the Manchester derby, he said, “It’s a regional classic that is very strong, you know. It’s the classic of the city.
“So really when you have a game against City, you really have blood in your eyes.
“Of course, against Liverpool, it’s even bigger, you have more blood in your eyes, because there is the whole story that involves everything, the history of the two teams is huge in world football. “
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Fred, speaking to Esporte Interativo, added: “But against City, it’s also a great game and our city classic. You have to show who runs the city. “